Cnnm2^tm1.1Hmik
Targeted Allele Detail

Summary

• Symbol: Cnnm2^tm1.1Hmik
• Name: cyclin M2; targeted mutation 1.1, Hiroaki Miki
• MGI ID: MGI:6690510
• Synonyms: Cnnm2^delta
• Gene: Cnnm2 Location: Chr19:46750035-46868631 bp, + strand Genetic Position: Chr19, 38.97 cM
• Alliance: Cnnm2^tm1.1Hmik page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:303151
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An FRT site, a beta-galactosidase gene cassette, a neomycin resistance gene cassette, a second FRT site and a loxP site were inserted into intron 1 and a second loxP site into intron 4. Introns 2-4 were deleted through subsequent cre-mediated recombination. (J:303151)

Expression

In Mice Carrying this Mutation:	13 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cnnm2 Mutation: 98 strains or lines available

References

• Original: J:303151 Funato Y, et al., Renal function of cyclin M2 Mg2+ transporter maintains blood pressure. J Hypertens. 2017 Mar;35(3):585-592
• All: 3 reference(s)