Phenotypes associated with this allele

• Allele Symbol: Syngr3^em1Pave
• Allele Name: endonuclease-mediated mutation 1, Patrik Verstreken
• Allele ID: MGI:6690242
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Syngr3^em1Pave/Syngr3^em1Pave	C57BL/6-Syngr3^em1Pave	MGI:6690264
cx2	Syngr3^em1Pave/Syngr3^+ Tg(Prnp-MAPT*P301S)PS19Vle/0	involves: C3H * C57BL/6	MGI:6690265

Genotype
MGI:6690264

hm1

• Allelic Composition: Syngr3^em1Pave/Syngr3^em1Pave
• Genetic Background: C57BL/6-Syngr3^em1Pave

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:303506 )

N • normal motor behavior

embryo

embryo phenotype ( J:303506 )

N • born at expected Mendelian ratio

growth/size/body

growth/size/body region phenotype ( J:303506 )

N • normal body weight, no gross abnormalities

mortality/aging

mortality/aging ( J:303506 )

N • viable, normal lifespan

reproductive system

reproductive system phenotype ( J:303506 )

N • fertile

Genotype
MGI:6690265

cx2

• Allelic Composition: Syngr3^em1Pave/Syngr3⁺; Tg(Prnp-MAPT*P301S)PS19Vle/0
• Genetic Background: involves: C3H * C57BL/6

behavior/neurological

behavior/neurological phenotype ( J:303506 )

N • normal working memory as evidenced by performance in Morris water maze test at age 6-7 months

hematopoietic system

microgliosis ( J:303506 )

• increased number of activated microglia in stratum lucidum

immune system

microgliosis ( J:303506 )

• increased number of activated microglia in stratum lucidum

nervous system

nervous system phenotype ( J:303506 )

N • normal long-term potentiation response to three-theta-burst-stimulation (TBS) in mossy fiber CA3 synapses at age 6-7 months

N • normal long-term potentiation response in Schaffer collateral CA1 synapses at age 8 months

N • no loss of synapses in synaptic stratum lucidum area at age 8-9 months

N • normal number of mossy fiber boutons at age 8-9 months

astrocytosis ( J:303506 )

• increased number of reactive astrocytes in stratum lucidum

microgliosis ( J:303506 )

• increased number of activated microglia in stratum lucidum

cellular

astrocytosis ( J:303506 )

• increased number of reactive astrocytes in stratum lucidum

microgliosis ( J:303506 )

• increased number of activated microglia in stratum lucidum