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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ttll8tm1.2Ics
targeted mutation 1.2, Mouse Clinical Institute
MGI:6514903
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Ttll3tm1.2Ics/Ttll3tm1.2Ics
Ttll8tm1.2Ics/Ttll8tm1.2Ics 		B6.129S2-Ttll3tm1.2Ics Ttll8tm1.2Ics MGI:6515558


Genotype
MGI:6515558
cx1
Allelic
Composition		 Ttll3tm1.2Ics/Ttll3tm1.2Ics
Ttll8tm1.2Ics/Ttll8tm1.2Ics
Genetic
Background		 B6.129S2-Ttll3tm1.2Ics Ttll8tm1.2Ics
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ttll3tm1.2Ics mutation (0 available); any Ttll3 mutation (85 available)
Ttll8tm1.2Ics mutation (0 available); any Ttll8 mutation (38 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
kinked sperm flagellum ( J:300009 )
• flagellar curvature is more than 3 times higher than in wild-type cells
decreased sperm progressive motility ( J:300009 )
• with decreased curvilinear velocity, straight-line velocity, and average path velocity
• asymmetrical flagella beating, premature hyperactivation, and circular swimming paths
decreased fertilization frequency ( J:300009 )
• in vitro fertilization using double null sperm is one fourth of wild-type sperm

nervous system
nervous system phenotype ( J:300009 )
N
• mice exhibit normal ependymal cilia morphology and function with no sign of hydrocephaly

renal/urinary system
renal/urinary system phenotype ( J:300009 )
N
• mice exhibit normal primary cilia from kidney collecting tubules with no polycystic kidneys

respiratory system
respiratory system phenotype ( J:300009 )
N
• mice exhibit normal trachea cilia

cellular
kinked sperm flagellum ( J:300009 )
• flagellar curvature is more than 3 times higher than in wild-type cells
decreased sperm progressive motility ( J:300009 )
• with decreased curvilinear velocity, straight-line velocity, and average path velocity
• asymmetrical flagella beating, premature hyperactivation, and circular swimming paths




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory