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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rfx7tm1.1Ggaur
targeted mutation 1.1, Greta Guarda
MGI:6513141
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Rfx7tm1.1Ggaur/Rfx7tm1.1Ggaur
Rptortm1.1Dmsa/Rptor+
Commd10Tg(Vav1-icre)A2Kio/Commd10+ 		involves: 129S/SvEv * C57BL/10 * CBA/Ca MGI:6513971
cn2
 		Rfx7tm1.1Ggaur/Rfx7tm1.1Ggaur
Ncr1tm1.1(icre)Viv/Ncr1+ 		involves: C57BL/6 MGI:6513975
cn3
 		Rfx7tm1.1Ggaur/Rfx7tm1.1Ggaur
Commd10Tg(Vav1-icre)A2Kio/Commd10+ 		involves: C57BL/6 * C57BL/10 * CBA/Ca MGI:6513967


Genotype
MGI:6513971
cn1
Allelic
Composition		 Rfx7tm1.1Ggaur/Rfx7tm1.1Ggaur
Rptortm1.1Dmsa/Rptor+
Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic
Background		 involves: 129S/SvEv * C57BL/10 * CBA/Ca
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Commd10Tg(Vav1-icre)A2Kio mutation (3 available); any Commd10 mutation (24 available)
Rfx7tm1.1Ggaur mutation (0 available); any Rfx7 mutation (78 available)
Rptortm1.1Dmsa mutation (1 available); any Rptor mutation (115 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal NK cell morphology ( J:282535 )
• reduced cell size and granularity but not as much as in Rfx7tm1.1Ggaur/Rfx7tm1.1Ggaur Commd10Tg(Vav1-icre)A2Kio/Commd10+ mice
decreased NK cell number ( J:282535 )
• although not as decreased in Rfx7tm1.1Ggaur/Rfx7tm1.1Ggaur Commd10Tg(Vav1-icre)A2Kio/Commd10+ mice

hematopoietic system
abnormal NK cell morphology ( J:282535 )
• reduced cell size and granularity but not as much as in Rfx7tm1.1Ggaur/Rfx7tm1.1Ggaur Commd10Tg(Vav1-icre)A2Kio/Commd10+ mice
decreased NK cell number ( J:282535 )
• although not as decreased in Rfx7tm1.1Ggaur/Rfx7tm1.1Ggaur Commd10Tg(Vav1-icre)A2Kio/Commd10+ mice




Genotype
MGI:6513975
cn2
Allelic
Composition		 Rfx7tm1.1Ggaur/Rfx7tm1.1Ggaur
Ncr1tm1.1(icre)Viv/Ncr1+
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ncr1tm1.1(icre)Viv mutation (1 available); any Ncr1 mutation (39 available)
Rfx7tm1.1Ggaur mutation (0 available); any Rfx7 mutation (78 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased NK cell number ( J:282535 )
• in the spleen, blood, and liver
• mice infected with murine cytomegalovirus exhibit reduced total and Ly49H+ after 1.5 days infection and milder after 3.5 days compared with control mice
abnormal NK cell physiology ( J:282535 )
• decreased survival in vivo and in culture
• treatment with IL2-anti-IL2 complexes partially rescues the ability to reject B2m-deficient splenocytes
• slightly less granzyme A production in uninfected mice
• however, cells exhibit normal cell-mediated immunity when cultured with RMA-S and RMA-H60 target cells
• however, increased IL2 or IL15 amounts restores NK cell survival in culture
increased susceptibility to viral infection ( J:282535 )
• mice infected with murine cytomegalovirus exhibit reduced total and Ly49H+ after 1.5 days infection and milder after 3.5 days with reduced granzyme B production and higher viral loads early after infection in the spleen and lungs compared with control mice
• however, IFNG production from NK cells of cytomegalovirus virus-infected mice

hematopoietic system
decreased NK cell number ( J:282535 )
• in the spleen, blood, and liver
• mice infected with murine cytomegalovirus exhibit reduced total and Ly49H+ after 1.5 days infection and milder after 3.5 days compared with control mice
abnormal NK cell physiology ( J:282535 )
• decreased survival in vivo and in culture
• treatment with IL2-anti-IL2 complexes partially rescues the ability to reject B2m-deficient splenocytes
• slightly less granzyme A production in uninfected mice
• however, cells exhibit normal cell-mediated immunity when cultured with RMA-S and RMA-H60 target cells
• however, increased IL2 or IL15 amounts restores NK cell survival in culture




Genotype
MGI:6513967
cn3
Allelic
Composition		 Rfx7tm1.1Ggaur/Rfx7tm1.1Ggaur
Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic
Background		 involves: C57BL/6 * C57BL/10 * CBA/Ca
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Commd10Tg(Vav1-icre)A2Kio mutation (3 available); any Commd10 mutation (24 available)
Rfx7tm1.1Ggaur mutation (0 available); any Rfx7 mutation (78 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal NK cell morphology ( J:282535 )
• reduced cell size and granularity but not as much as in Rfx7tm1.1Ggaur/Rfx7tm1.1Ggaur Commd10Tg(Vav1-icre)A2Kio/Commd10+ mice
decreased NK cell number ( J:282535 )
• although not as decreased in Rfx7tm1.1Ggaur/Rfx7tm1.1Ggaur Commd10Tg(Vav1-icre)A2Kio/Commd10+ mice

hematopoietic system
abnormal NK cell morphology ( J:282535 )
• reduced cell size and granularity but not as much as in Rfx7tm1.1Ggaur/Rfx7tm1.1Ggaur Commd10Tg(Vav1-icre)A2Kio/Commd10+ mice
decreased NK cell number ( J:282535 )
• although not as decreased in Rfx7tm1.1Ggaur/Rfx7tm1.1Ggaur Commd10Tg(Vav1-icre)A2Kio/Commd10+ mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory