Analysis Tools
mortality/aging
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• the few live-born pups were cyanotic and died within 1 hr after birth from respiratory failure
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respiratory system
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Allele Symbol Allele Name Allele ID |
Borcs5em1Jusb endonuclease-mediated mutation 1, Juan S Bonifacino MGI:6510587 |
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| Summary |
3 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• the few live-born pups were cyanotic and died within 1 hr after birth from respiratory failure
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• the few live-born pups were cyanotic and died within 1 hr after birth from respiratory failure
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• normal ante- and retrograde axonal transport of synaptic vesicle precursors (SVPs) in E18 embryo neurons in vitro; presence of SVPs in corpus callosum axons and hippocampus molecular layer axons and dendrites in E18 embryos
• presence of synaptic vesicle precursor (SVPs) in diaphragm neuromuscular junctions in E18 embryos
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• swollen axons in phrenic and spinal nerves of E18 embryos
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• absence of lysosomes from diaphragm neuromuscular junctions (NMJs) in E18 embryos
• presence of synaptic vesicle precursor (SVPs) in diaphragm NMJs in E18 embryos
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• no axonal transport of lysosomes in E18 embryo neurons in vitro; lysosomes mostly absent from corpus callosum axons and hippocampus molecular layer axons and dendrites in E18 embryos
• absence of lysosomes from diaphragm neuromuscular junctions (NMJs) in E18 embryos
• normal presence of lysosomes in neuronal cell bodies in hippocampus pyramidal layer and CA1 and CA3 regions in E18 embryos
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• the few live-born pups were cyanotic and died within 1 hr after birth from respiratory failure
• normal Mendelian ratios at E18 stage
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/14/2024 MGI 6.23 |
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