Phenotypes associated with this allele

• Allele Symbol: Sprr2f^em1Jadb
• Allele Name: endonuclease-mediated mutation 1, James D Brooks
• Allele ID: MGI:6510021
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sprr2f^em1Jadb/Sprr2f^em1Jadb	C57BL/6-Sprr2f^em1Jadb	MGI:6510023

Genotype
MGI:6510023

hm1

• Allelic Composition: Sprr2f^em1Jadb/Sprr2f^em1Jadb
• Genetic Background: C57BL/6-Sprr2f^em1Jadb

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

renal/urinary system

renal fibrosis ( J:299874 )

• significantly increased kidney fibrosis after unilateral ureteral obstruction (UUO)

homeostasis/metabolism

abnormal susceptibility to injury induced morbidity/mortality ( J:299874 )

• significantly greater renal damage (acute kidney injury (AKI)) after bilateral ischemia-reperfusion injury (IRI) to kidneys

cellular

increased cellular sensitivity to oxidative stress ( J:299874 )

mortality/aging

abnormal susceptibility to injury induced morbidity/mortality ( J:299874 )

• significantly greater renal damage (acute kidney injury (AKI)) after bilateral ischemia-reperfusion injury (IRI) to kidneys

increased susceptibility to induced morbidity/mortality ( J:299874 )

• significantly greater renal damage (acute kidney injury (AKI)) after bilateral ischemia-reperfusion injury (IRI) to kidneys

• significantly increased kidney fibrosis after unilateral ureteral obstruction (UUO)

growth/size/body

growth/size/body region phenotype ( J:299874 )

N • normal weight, size and growth; no obvious organ abnormalities

reproductive system

reproductive system phenotype ( J:299874 )

N • fertile; normal litter sizes with normal sex distribution