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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Nlrc4em1Vnce
endonuclease-mediated mutation 1, Russell E Vance
MGI:6508701
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Nlrc4em1Vnce/Nlrc4em1Vnce C57BL/6-Nlrc4em1Vnce MGI:6509145
cx2
 		Nlrc4em1Vnce/Nlrc4em1Vnce
Nlrp3tm1Vmd/Nlrp3tm1Vmd 		involves: C57BL/6J * C57BL/6N MGI:6509153


Genotype
MGI:6509145
hm1
Allelic
Composition		 Nlrc4em1Vnce/Nlrc4em1Vnce
Genetic
Background		 C57BL/6-Nlrc4em1Vnce
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nlrc4em1Vnce mutation (2 available); any Nlrc4 mutation (72 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
decreased lactate dehydrogenase level ( J:294930 )
• no LDH released by bone marrow derived macrophages exposed to cytosolic Legionella pneumophila flagellin whether primed with LPS or not

immune system
decreased inflammatory response ( J:294930 )
• no inflammatory response by bone marrow derived macrophages exposed to cytosolic Legionella pneumophila flagellin (whether primed with LPS or not) or to Salmonella Typhimuriu
• no inflammatory response after exposure to Legionella pneumophila flagellin
increased susceptibility to bacterial infection induced morbidity/mortality ( J:294930 )
• no inflammatory response after oral exposure to S. Typhimurium, resulting in increased bacterial load in cecal tissue and lymph nodes

mortality/aging
mortality/aging ( J:294930 )
N
• viable
increased susceptibility to bacterial infection induced morbidity/mortality ( J:294930 )
• no inflammatory response after oral exposure to S. Typhimurium, resulting in increased bacterial load in cecal tissue and lymph nodes

reproductive system




Genotype
MGI:6509153
cx2
Allelic
Composition		 Nlrc4em1Vnce/Nlrc4em1Vnce
Nlrp3tm1Vmd/Nlrp3tm1Vmd
Genetic
Background		 involves: C57BL/6J * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nlrc4em1Vnce mutation (2 available); any Nlrc4 mutation (72 available)
Nlrp3tm1Vmd mutation (0 available); any Nlrp3 mutation (69 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
decreased lactate dehydrogenase level ( J:294930 )
• severe reduction in LDH released by bone marrow derived macrophages exposed to Salmonella Typhimurium

immune system
decreased inflammatory response ( J:294930 )
• severe reduction in inflammatory response by bone marrow derived macrophages exposed to Salmonella Typhimurium




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory