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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Fancmem1Qsh
endonuclease-mediated mutation 1, Qinghua Shi
MGI:6508081
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Fancmem1Qsh/Fancmem1Qsh C57BL/6-Fancmem1Qsh MGI:6508101


Genotype
MGI:6508101
hm1
Allelic
Composition
Fancmem1Qsh/Fancmem1Qsh
Genetic
Background
C57BL/6-Fancmem1Qsh
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fancmem1Qsh mutation (0 available); any Fancm mutation (119 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
• round spermatids as most developed stage in 43.5% of tubules
• in adult mice
• age-related progressive reduction in spermatogonial stem cell to Sertoli cell ratio
• increased sensitivity of spermatogonia to mitomycin C
• 7.6% of tubules Sertoli cell only (SCO)
• loss of germ cells of multiple stages in 42.6% of tubules
• round spermatids as most developed stage in 43.5% of tubules
• large proportion of atypical stage IIVI tubules lacking elongating/ed spermatids in adult testes
• reduced stage VII-XII tubule frequency

cellular
• round spermatids as most developed stage in 43.5% of tubules
• increased sensitivity of spermatogonia to mitomycin C
• in adult mice
• age-related progressive reduction in spermatogonial stem cell to Sertoli cell ratio
• increased sensitivity of spermatogonia to mitomycin C

endocrine/exocrine glands
• 7.6% of tubules Sertoli cell only (SCO)
• loss of germ cells of multiple stages in 42.6% of tubules
• round spermatids as most developed stage in 43.5% of tubules
• large proportion of atypical stage IIVI tubules lacking elongating/ed spermatids in adult testes
• reduced stage VII-XII tubule frequency

neoplasm
N
• no cancer incidence in 1st year

hematopoietic system
N
• normal blood cell count, hemoglobin levels and other hematological parameters





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last database update
05/07/2024
MGI 6.23
The Jackson Laboratory