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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cacng2em1Tern
endonuclease-mediated mutation 1, Terunaga Nakagawa
MGI:6505622
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Cacng2em1Tern/Cacng2em1Tern C57BL/6J-Cacng2em1Tern MGI:6506057
cx2
 		Cacng2em1Tern/Cacng2em1Tern
Gsg1ltm1.2Tern/Gsg1ltm1.2Tern 		C57BL/6J-Cacng2em1Tern Gsg1ltm1.2Tern MGI:6506055


Genotype
MGI:6506057
hm1
Allelic
Composition		 Cacng2em1Tern/Cacng2em1Tern
Genetic
Background		 C57BL/6J-Cacng2em1Tern
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cacng2em1Tern mutation (0 available); any Cacng2 mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal miniature excitatory postsynaptic currents ( J:301313 )
• reduced AMPA-type ionotropic glutamate receptor (AMPAR)-mediated miniature EPSC (mEPSC) amplitude and frequency in subset of AD/AV (anterodorsal nucleus and anteroventral nucleus in anterior thalamus (AT)) neurons
decreased miniature excitatory postsynaptic current amplitude ( J:301313 )
• reduced AMPA-type ionotropic glutamate receptor (AMPAR)-mediated miniature EPSC (mEPSC) amplitude in subset of AD/AV (anterodorsal nucleus and anteroventral nucleus in anterior thalamus (AT)) neurons
decreased miniature excitatory postsynaptic current frequency ( J:301313 )
• reduced AMPA-type ionotropic glutamate receptor (AMPAR)-mediated miniature EPSC (mEPSC) frequency in subset of AD/AV (anterodorsal nucleus and anteroventral nucleus in anterior thalamus (AT)) neurons




Genotype
MGI:6506055
cx2
Allelic
Composition		 Cacng2em1Tern/Cacng2em1Tern
Gsg1ltm1.2Tern/Gsg1ltm1.2Tern
Genetic
Background		 C57BL/6J-Cacng2em1Tern Gsg1ltm1.2Tern
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cacng2em1Tern mutation (0 available); any Cacng2 mutation (26 available)
Gsg1ltm1.2Tern mutation (0 available); any Gsg1l mutation (15 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
increased excitatory postsynaptic current amplitude ( J:301313 )
• increased AMPA-type ionotropic glutamate receptor (AMPAR)-mediated spontaneous EPSC (sEPSC) amplitude and frequency in AD/AV (anterodorsal nucleus and anteroventral nucleus in anterior thalamus (AT)) neurons
short excitatory postsynaptic current decay time ( J:301313 )
• reduced miniature EPSC (mEPSC) decay time in AD/AV (anterodorsal nucleus and anteroventral nucleus in anterior thalamus (AT)) neurons
short excitatory postsynaptic current rise time ( J:301313 )
• reduced miniature EPSC (mEPSC) rise time in AD/AV (anterodorsal nucleus and anteroventral nucleus in anterior thalamus (AT)) neurons
abnormal miniature excitatory postsynaptic currents ( J:301313 )
• increased AMPA-type ionotropic glutamate receptor (AMPAR)-mediated miniature EPSC (mEPSC) amplitude and frequency in AD/AV (anterodorsal nucleus and anteroventral nucleus in anterior thalamus (AT)) neurons




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/14/2024
MGI 6.23 		The Jackson Laboratory