Analysis Tools
homeostasis/metabolism
| N |
• despite an 80% reduction in Larp1 expression by islets, male mice exhibit no difference in glucose tolerance relative to control males
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Allele Symbol Allele Name Allele ID |
Larp1tm1c(EUCOMM)Hmgu targeted mutation 1c, Helmholtz Zentrum Muenchen GmbH MGI:6505556 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• despite an 80% reduction in Larp1 expression by islets, male mice exhibit no difference in glucose tolerance relative to control males
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• mice exhibit normal glucose homeostasis with no differences in body weight, non-fasting and fasting glycemia, non-fasting plasma insulin, and glucose tolerance observed in males at 4, 8 and 14 weeks of age, or in glucose tolerance observed in females at 13-14 weeks of age relative to gender- and age-matched controls
• aged male mice show normal body weight and glucose tolerance at 44 weeks of age
• islets isolated from 7-month old male mice show normal glucose-stimulated insulin secretion with no differences in insulin content relative to control values
• glucose metabolism is relatively normal even after exposure to a high fat diet or a high branched chain amino acid (BCAA) diet for 8 weeks
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• after long-term exposure (16 weeks) to a BCAA diet, mice exhibit slightly impaired glucose tolerance relative to controls; however, no significant differences in plasma insulin levels, non fasting glycemia, beta cell mass or islet morphology are observed
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/14/2024 MGI 6.23 |
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