Analysis Tools
mortality/aging
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• mice inoculated intracerebrally with the attenuated Edmonston measles virus (MV-Edm) show increased lethality after two days post infection
• 50% of mice inoculated with the rat brain-adapted neurotrophic measles virus strain CAM/RBH succumb 5-11 days post infection
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immune system
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• mice infected intracerebrally with MV-Edm show encephalitis
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meningitis
(
J:160878
)
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• mice infected intracerebrally with MV-Edm exhibit meningitis with inflammatory infiltrates of leukocytes and extensive vacuolization and necrosis of nearby brain parenchyma
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• mice inoculated intranasally with MV-Edm show acute lung inflammation
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• mice inoculated intranasally with the attenuated Edmonston measles virus (MV-Edm)
• mice inoculated intranasally with MV-Edm show acute lung inflammation, extensive hyperemia, and diffuse hemorrhage in large areas of the lungs and show peak virus levels in the lungs at day 6 post infection which spreads to liver, spleen, kidney, and peripheral blood mononuclear cells
• susceptibility to MV-Edm infection is more pronounced if less virus is inoculated
• mice inoculated intracerebrally with MV-Edm show increased lethality after two days post infection and show clinical signs of neural disease, including initial hyperactivity followed by awkward gait, lethargy, lack of mobility, and death
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• mice inoculated intracerebrally with the attenuated Edmonston measles virus (MV-Edm) show increased lethality after two days post infection
• 50% of mice inoculated with the rat brain-adapted neurotrophic measles virus strain CAM/RBH succumb 5-11 days post infection
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respiratory system
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• mice inoculated intranasally with MV-Edm show diffuse hemorrhage in large areas of the lungs
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• mice inoculated intranasally with MV-Edm show extensive hyperemia
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• mice inoculated intranasally with MV-Edm show acute lung inflammation
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nervous system
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• mice infected intracerebrally with MV-Edm show encephalitis
|
meningitis
(
J:160878
)
|
• mice infected intracerebrally with MV-Edm exhibit meningitis with inflammatory infiltrates of leukocytes and extensive vacuolization and necrosis of nearby brain parenchyma
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astrocytosis
(
J:160878
)
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• mice infected intracerebrally with MV-Edm show numerous reactive astrocytes in many brain areas
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• mice infected intracerebrally with MV-Edm exhibit necrosis of neurons in the cerebral cortex, corpus callosum, and hypothalamus
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behavior/neurological
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• mice inoculated intracerebrally with MV-Edm show initial hyperactivity that is followed by awkward gait and lethargy
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• mice inoculated intracerebrally with MV-Edm show initial hyperactivity followed by awkward gait and lack of mobility
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• mice inoculated intracerebrally with MV-Edm show initial hyperactivity following infection
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cardiovascular system
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• mice inoculated intranasally with MV-Edm show diffuse hemorrhage in large areas of the lungs
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• mice inoculated intranasally with MV-Edm show extensive hyperemia
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