All Phenotypes Arhgef7<tm1d(EUCOMM)Wtsi> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Arhgef7^{tm1d(EUCOMM)Wtsi}
targeted mutation 1d, Wellcome Trust Sanger Institute
MGI:6501603

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Arhgef7^{tm1d(EUCOMM)Wtsi}/Arhgef7^{tm1d(EUCOMM)Wtsi}	involves: C57BL/6N * CBA	MGI:6841000

Allelic Composition	Arhgef7^{tm1d(EUCOMM)Wtsi}/Arhgef7^{tm1d(EUCOMM)Wtsi}
Genetic Background	involves: C57BL/6N * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Arhgef7^{tm1d(EUCOMM)Wtsi} mutation (0 available); any Arhgef7 mutation (53 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality between somite formation and embryo turning, complete penetrance ( J:217373 )

• mice die at about E8.5

embryo

abnormal anterior visceral endoderm cell migration ( J:217373 )

• with reduced directional persistence of migration, small reduction of individual cell migration speed, loss of collectivity, and impaired directing of protrusive activity

abnormal embryo development ( J:217373 )

• at E6.5 and E8.5

abnormal primitive streak morphology ( J:217373 )

• double axis

cellular

abnormal anterior visceral endoderm cell migration ( J:217373 )

• with reduced directional persistence of migration, small reduction of individual cell migration speed, loss of collectivity, and impaired directing of protrusive activity

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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