Phenotypes associated with this allele

• Allele Symbol: Sbsn^em1Ham
• Allele Name: endonuclease-mediated mutation 1, Hamamatsu University School of Medicine
• Allele ID: MGI:6500980
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sbsn^em1Ham/Sbsn^em1Ham	C57BL/6N-Sbsn^em1Ham	MGI:6500993

Genotype
MGI:6500993

hm1

• Allelic Composition: Sbsn^em1Ham/Sbsn^em1Ham
• Genetic Background: C57BL/6N-Sbsn^em1Ham

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:296400 )

N • mice exhibit normal response to ovalbumin-specific IgE response

decreased susceptibility to type IV hypersensitivity reaction ( J:296400 )

• in response to haptens, mice produce lower frequencies of IL4+CD4+ T cells compared with wild-type mice

• however, there is no difference in the Langerhans cell number

increased susceptibility to type IV hypersensitivity reaction ( J:296400 )

• response to nickel loading mice exhibit increased ear swelling compared with wild-type mice

decreased interleukin-4 secretion ( J:296400 )

• in response to haptens, mice produce lower frequencies of IL4+CD4+ T cells compared with wild-type mice

integument

impaired skin barrier function ( J:296400 )

• at E16.5, but not P0

abnormal epidermis stratum corneum morphology ( J:296400 )

• scarce, immature, and fragile in newborn mice

• fragile in older mice

homeostasis/metabolism

abnormal blood homeostasis ( J:296400 )

• elevated nickel level after oral nickel loading

impaired skin barrier function ( J:296400 )

• at E16.5, but not P0