Phenotypes associated with this allele

• Allele Symbol: Pole3^em4Tbo
• Allele Name: endonuclease-mediated mutation 4, Thomas Boehm
• Allele ID: MGI:6490636
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pole3^em4Tbo/Pole3^em4Tbo	FVB-Pole3^em4Tbo	MGI:6491472

Genotype
MGI:6491472

hm1

• Allelic Composition: Pole3^em4Tbo/Pole3^em4Tbo
• Genetic Background: FVB-Pole3^em4Tbo

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

increased thymocyte apoptosis ( J:298827 )

• increased apoptosis in DN1, DN2 and DN3 thymocytes

abnormal thymus apoptosis ( J:298827 )

• increased apoptosis in DN1, DN2 and DN3 thymocytes

immune system

increased thymocyte apoptosis ( J:298827 )

• increased apoptosis in DN1, DN2 and DN3 thymocytes

abnormal thymus apoptosis ( J:298827 )

• increased apoptosis in DN1, DN2 and DN3 thymocytes

increased DN3 thymocyte number ( J:298827 )

• proportion of DN3 cells increased in thymus

decreased lymphocyte cell number ( J:298827 )

• significant reduction in number of CD4+, CD8+ and CD19+ cells in spleen

decreased thymocyte number ( J:298827 )

• significant reduction

decreased DN4 thymocyte number ( J:298827 )

• proportion of DN4 cells decreased in thymus

decreased B cell number ( J:298827 )

• reduction in number of B220+ cells in bone marrow

decreased immature B cell number ( J:298827 )

• in bone marrow

decreased pre-B cell number ( J:298827 )

• 3-fold reduction of B220+ IgM- CD43- cells in bone marrow

decreased splenocyte number ( J:298827 )

• significant reduction in number of CD4+, CD8+ and CD19+ cells in spleen

endocrine/exocrine glands

increased thymocyte apoptosis ( J:298827 )

• increased apoptosis in DN1, DN2 and DN3 thymocytes

abnormal thymus apoptosis ( J:298827 )

• increased apoptosis in DN1, DN2 and DN3 thymocytes

decreased thymocyte number ( J:298827 )

• significant reduction

decreased DN4 thymocyte number ( J:298827 )

• proportion of DN4 cells decreased in thymus

increased DN3 thymocyte number ( J:298827 )

• proportion of DN3 cells increased in thymus

hematopoietic system

increased thymocyte apoptosis ( J:298827 )

• increased apoptosis in DN1, DN2 and DN3 thymocytes

abnormal thymus apoptosis ( J:298827 )

• increased apoptosis in DN1, DN2 and DN3 thymocytes

increased DN3 thymocyte number ( J:298827 )

• proportion of DN3 cells increased in thymus

decreased lymphocyte cell number ( J:298827 )

• significant reduction in number of CD4+, CD8+ and CD19+ cells in spleen

decreased thymocyte number ( J:298827 )

• significant reduction

decreased DN4 thymocyte number ( J:298827 )

• proportion of DN4 cells decreased in thymus

decreased B cell number ( J:298827 )

• reduction in number of B220+ cells in bone marrow

decreased immature B cell number ( J:298827 )

• in bone marrow

decreased pre-B cell number ( J:298827 )

• 3-fold reduction of B220+ IgM- CD43- cells in bone marrow

decreased splenocyte number ( J:298827 )

• significant reduction in number of CD4+, CD8+ and CD19+ cells in spleen

embryo

embryo phenotype ( J:298827 )

N • no gross developmental anomalies

mortality/aging

mortality/aging ( J:298827 )

N • viable; born at expected Mendelian ratios

preweaning lethality, incomplete penetrance ( J:298827 )

• at 3 weeks post-partum only 10% alive