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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Pole3em3Tbo
endonuclease-mediated mutation 3, Thomas Boehm
MGI:6490635
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Pole3em3Tbo/Pole3em3Tbo FVB-Pole3em3Tbo MGI:6491465


Genotype
MGI:6491465
hm1
Allelic
Composition
Pole3em3Tbo/Pole3em3Tbo
Genetic
Background
FVB-Pole3em3Tbo
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pole3em3Tbo mutation (0 available); any Pole3 mutation (14 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• faster progression through S phase in DN3, DN4, and DP T cells
• increased apoptosis in DN1, DN2 and DN3 thymocytes
• increased apoptosis in DN1, DN2 and DN3 thymocytes

immune system
• increased apoptosis in DN1, DN2 and DN3 thymocytes
• increased apoptosis in DN1, DN2 and DN3 thymocytes
• proportion of DN3 cells increased in thymus
• reduction in number of CD4+, CD8+ and CD19+ cells in spleen
• significant reduction
• proportion of DN4 cells decreased in thymus
• 50-fold reduction in thymus
• reduction in number of B220+ cells in bone marrow
• 3-fold reduction of B220+ IgM- CD43- cells in bone marrow
• 2-fold reduction in thymus
• reduction in number of CD4+, CD8+ and CD19+ cells in spleen

endocrine/exocrine glands
• increased apoptosis in DN1, DN2 and DN3 thymocytes
• increased apoptosis in DN1, DN2 and DN3 thymocytes
• significant reduction
• proportion of DN4 cells decreased in thymus
• proportion of DN3 cells increased in thymus

hematopoietic system
• increased apoptosis in DN1, DN2 and DN3 thymocytes
• increased apoptosis in DN1, DN2 and DN3 thymocytes
• proportion of DN3 cells increased in thymus
• reduction in number of CD4+, CD8+ and CD19+ cells in spleen
• significant reduction
• proportion of DN4 cells decreased in thymus
• 50-fold reduction in thymus
• reduction in number of B220+ cells in bone marrow
• 3-fold reduction of B220+ IgM- CD43- cells in bone marrow
• 2-fold reduction in thymus
• reduction in number of CD4+, CD8+ and CD19+ cells in spleen

embryo
N
• no gross developmental anomalies

mortality/aging
N
• viable; born at expected Mendelian ratios





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/07/2024
MGI 6.23
The Jackson Laboratory