Phenotypes associated with this allele

• Allele Symbol: Trim16^tm1Gmma
• Allele Name: targeted mutation 1, Glenn M Marshall
• Allele ID: MGI:6479657
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Trim16^tm1Gmma/Trim16^+ Tg(KRT14-cre)1Cgn/0	involves: C57BL/6 * DBA/2	MGI:6479658
cn2	Trim16^tm1Gmma/Trim16^tm1Gmma Tg(KRT14-cre)1Cgn/0	involves: C57BL/6 * DBA/2	MGI:6479659

Genotype
MGI:6479658

cn1

• Allelic Composition: Trim16^tm1Gmma/Trim16⁺; Tg(KRT14-cre)1Cgn/0
• Genetic Background: involves: C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased incidence of tumors by chemical induction ( J:290272 )

• mice show increased incidence of DMBA and TPA-induced papillomas compared to wild-type mice and homozygotes

• 3 of 30 DMBA and TPA treated mice develop squamous cell carcinomas which are not seen in treated controls

• DMBA and TPA treated mice show an increase in the number of melanomas at 15 weeks compared to wild-type, with mice developing both small and large melanoma lesions after 21 weeks of TPA treatment compared to only small lesions in wild-type mice

increased metastatic potential ( J:290272 )

• 6 of 33 DMBA/TPA-treated mice show pigmentation in a number of inguinal lymph nodes, suggesting metastatic melanoma

decreased tumor latency ( J:290272 )

• DMBA and TPA treated mice show an increase in the development of papillomas at 13 and 15 weeks, but not weeks 18 and 21, indicating a decrease in latency of papilloma development

homeostasis/metabolism

increased incidence of tumors by chemical induction ( J:290272 )

• mice show increased incidence of DMBA and TPA-induced papillomas compared to wild-type mice and homozygotes

• 3 of 30 DMBA and TPA treated mice develop squamous cell carcinomas which are not seen in treated controls

• DMBA and TPA treated mice show an increase in the number of melanomas at 15 weeks compared to wild-type, with mice developing both small and large melanoma lesions after 21 weeks of TPA treatment compared to only small lesions in wild-type mice

Genotype
MGI:6479659

cn2

• Allelic Composition: Trim16^tm1Gmma/Trim16^tm1Gmma; Tg(KRT14-cre)1Cgn/0
• Genetic Background: involves: C57BL/6 * DBA/2

neoplasm

neoplasm ( J:290272 )

N • mice show similar development of DMBA and TPA-induced papillomas as wild-type mice, with no development of squamous cell carcinoma

N • mice show a similar incidence of DMBA/TPA-induced cutaneous melanomas as wild-type mice

increased tumor growth/size ( J:290272 )

• DMBA and TPA treated mice develop larger melanoma lesions than wild-type mice after 21 weeks of TPA treatment

behavior/neurological

behavior/neurological phenotype ( J:290272 )

N • mice exhibit normal food consumption