All Phenotypes Trp53<tm2Thst> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Trp53^tm2Thst
targeted mutation 2, Thorsten Stiewe
MGI:6479073

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Trp53^tm2Thst/Trp53⁺	involves: 129S1/Sv * 129X1/SvJ	MGI:6479114
ht2	Trp53^tm2Thst/Trp53^tm2.1Thst	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ	MGI:6479115

Allelic Composition	Trp53^tm2Thst/Trp53⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp53^tm2Thst mutation (1 available); any Trp53 mutation (232 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:282255 )

• median survival is 519 days

Allelic Composition	Trp53^tm2Thst/Trp53^tm2.1Thst
Genetic Background	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp53^tm2.1Thst mutation (1 available); any Trp53 mutation (232 available)
Trp53^tm2Thst mutation (1 available); any Trp53 mutation (232 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased tumor-free survival time ( J:282255 )

• mice develop tumors resulting in reduced survival (128 days)

neoplasm

abnormal tumor incidence ( J:282255 )

• mice develop tumors resulting in reduced survival (128 days)

• however, tumor metastatic potential is normal

increased testis tumor incidence ( J:282255 )

• in some mice

increased T cell derived lymphoma incidence ( J:282255 )

• dominant tumor type

increased B cell derived lymphoma incidence ( J:282255 )

• in some mice

increased carcinoma incidence ( J:282255 )

• in some mice

increased sarcoma incidence ( J:282255 )

• in some mice

endocrine/exocrine glands

increased testis tumor incidence ( J:282255 )

• in some mice

increased T cell derived lymphoma incidence ( J:282255 )

• dominant tumor type

reproductive system

increased testis tumor incidence ( J:282255 )

• in some mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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