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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Amigo2em#Dke
endonuclease-mediated mutation, Daniel Kerschensteiner
MGI:6478808
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Amigo2em#Dke/Amigo2em#Dke involves: C57BL/6J * DBA/2 MGI:6478838
cx2
Amigo1tm1.1(KOMP)Vlcg/Amigo1tm1.1(KOMP)Vlcg
Amigo2em#Dke/Amigo2em#Dke
involves: C57BL/6J * C57BL/6N * DBA/2 MGI:7449215


Genotype
MGI:6478838
hm1
Allelic
Composition
Amigo2em#Dke/Amigo2em#Dke
Genetic
Background
involves: C57BL/6J * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Amigo2em#Dke mutation (0 available); any Amigo2 mutation (25 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• increased dendrite size and larger occupied territory of mid-eccentricity ON and OFF SACs
• normal dendrite arbor branch distribution relative to dendrite size of mid-eccentricity ON and OFF SACs
• normal density of mid-eccentricity ON SACs and their distribution in ganglion cell layer as measured by density recovery profiles
• normal density of mid-eccentricity OFF SACs and their distribution in inner nuclear layer
• normal stratification of mid-eccentricity SAC dendrites in inner plexiform layer (IPL)
• increased dendrite size and larger occupied territory mid-eccentricity RBCs
• normal density in inner nuclear layer of mid-eccentricity RBCs
• normal stratification of mid-eccentricity RBC axons in inner plexiform layer (IPL)
• normal input synapse distribution on mid-eccentricity RBC dendrites relative to dendrite size
• normal axon territory size
• enhanced direction selectivity of DSGC responses to starburst amacrine cell signals

vision/eye
N
• normal retina surface area
• normal stratification of starburst amacrine cell (SAC) and retinal rod bipolar cell (RBC) neurites in inner plexiform layer (IPL)
• normal horizontal cell axon and dendrite size
• increased dendrite size and larger occupied territory of mid-eccentricity ON and OFF SACs
• normal dendrite arbor branch distribution relative to dendrite size of mid-eccentricity ON and OFF SACs
• normal density of mid-eccentricity ON SACs and their distribution in ganglion cell layer as measured by density recovery profiles
• normal density of mid-eccentricity OFF SACs and their distribution in inner nuclear layer
• normal stratification of mid-eccentricity SAC dendrites in inner plexiform layer (IPL)
• increased dendrite size and larger occupied territory mid-eccentricity RBCs
• normal density in inner nuclear layer of mid-eccentricity RBCs
• normal stratification of mid-eccentricity RBC axons in inner plexiform layer (IPL)
• normal input synapse distribution on mid-eccentricity RBC dendrites relative to dendrite size
• normal axon territory size
• enhanced direction selectivity of DSGC responses to starburst amacrine cell signals




Genotype
MGI:7449215
cx2
Allelic
Composition
Amigo1tm1.1(KOMP)Vlcg/Amigo1tm1.1(KOMP)Vlcg
Amigo2em#Dke/Amigo2em#Dke
Genetic
Background
involves: C57BL/6J * C57BL/6N * DBA/2
Cell Lines 10669A-E11
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Amigo1tm1.1(KOMP)Vlcg mutation (1 available); any Amigo1 mutation (22 available)
Amigo2em#Dke mutation (0 available); any Amigo2 mutation (25 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
N
• dark-adapted a- and b-wave amplitudes and light-adapted b-wave amplitudes are not significantly different from those in wild-type controls, indicating normal ERG responses





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last database update
05/14/2024
MGI 6.23
The Jackson Laboratory