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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Alktm1.1(ALK*F1174L)Heno
targeted mutation 1.1, Hideki Enomoto
MGI:6476969
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Alktm1.1(ALK*F1174L)Heno/Alktm1.1(ALK*F1174L)Heno involves: 129X1/SvJ * C57BL/6 * C57BL/6N * SJL MGI:6476975
cn2
 		Alktm1.1(ALK*F1174L)Heno/Alktm1.1(ALK*F1174L)Heno
Tg(Mpz-cre)94Imeg/0
Tg(Th-MYCN)41Waw/0 		involves: 129X1/SvJ * BALB/c * C57BL/6 * SJL MGI:6476981
cn3
 		Alktm1.1(ALK*F1174L)Heno/Alk+
Tg(Mpz-cre)94Imeg/0
Tg(Th-MYCN)41Waw/0 		involves: 129X1/SvJ * BALB/c * C57BL/6 * SJL MGI:6476983
cn4
 		Alktm1.1(ALK*F1174L)Heno/Alktm1.1(ALK*F1174L)Heno
Tmem163Tg(ACTB-cre)2Mrt/Tmem163+ 		involves: 129X1/SvJ * C57BL/6 * C57BL/6N * FVB/N * SJL MGI:6476978
cn5
 		Alktm1.1(ALK*F1174L)Heno/Alktm1.1(ALK*F1174L)Heno
Tg(Mpz-cre)94Imeg/0 		involves: 129X1/SvJ * C57BL/6 * C57BL/6N * SJL MGI:6476976


Genotype
MGI:6476975
hm1
Allelic
Composition		 Alktm1.1(ALK*F1174L)Heno/Alktm1.1(ALK*F1174L)Heno
Genetic
Background		 involves: 129X1/SvJ * C57BL/6 * C57BL/6N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Alktm1.1(ALK*F1174L)Heno mutation (0 available); any Alk mutation (62 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:294092 )
• mice show normal appearance and fertility




Genotype
MGI:6476981
cn2
Allelic
Composition		 Alktm1.1(ALK*F1174L)Heno/Alktm1.1(ALK*F1174L)Heno
Tg(Mpz-cre)94Imeg/0
Tg(Th-MYCN)41Waw/0
Genetic
Background		 involves: 129X1/SvJ * BALB/c * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Alktm1.1(ALK*F1174L)Heno mutation (0 available); any Alk mutation (62 available)
Tg(Mpz-cre)94Imeg mutation (0 available)
Tg(Th-MYCN)41Waw mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:294092 )
• mice show enhanced lethality compared to single Tg(Th-MYCN)41Waw expressing mice

neoplasm
increased neuroblastoma incidence ( J:294092 )
• mice develop neuroblastoma with earlier onset, higher penetrance and enhanced lethality than in single Tg(Th-MYCN)41Waw expressing mice
decreased tumor latency ( J:294092 )
• mice show earlier onset of neuroblastoma than in single Tg(Th-MYCN)41Waw expressing mice

nervous system
increased neuroblastoma incidence ( J:294092 )
• mice develop neuroblastoma with earlier onset, higher penetrance and enhanced lethality than in single Tg(Th-MYCN)41Waw expressing mice

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
neuroblastoma DOID:769 J:294092




Genotype
MGI:6476983
cn3
Allelic
Composition		 Alktm1.1(ALK*F1174L)Heno/Alk+
Tg(Mpz-cre)94Imeg/0
Tg(Th-MYCN)41Waw/0
Genetic
Background		 involves: 129X1/SvJ * BALB/c * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Alktm1.1(ALK*F1174L)Heno mutation (0 available); any Alk mutation (62 available)
Tg(Mpz-cre)94Imeg mutation (0 available)
Tg(Th-MYCN)41Waw mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
decreased tumor-free survival time ( J:294092 )
• mice that develop thoracic and/or abdominal tumors die by 6 months

neoplasm
increased neuroblastoma incidence ( J:294092 )
• 17 of 18 mice develop bulky thoracic and/or abdominal tumors, with tumors showing features characteristic of neuroblastoma
• 14 of 18 mice exhibit abdominal tumors
• 4 of 18 mice exhibit thoracic tumors
• 2 of 18 mice exhibit both abdominal and thoracic tumors

nervous system
increased neuroblastoma incidence ( J:294092 )
• 2 of 18 mice exhibit both abdominal and thoracic tumors
• 17 of 18 mice develop bulky thoracic and/or abdominal tumors, with tumors showing features characteristic of neuroblastoma
• 14 of 18 mice exhibit abdominal tumors
• 4 of 18 mice exhibit thoracic tumors

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
neuroblastoma DOID:769 J:294092




Genotype
MGI:6476978
cn4
Allelic
Composition		 Alktm1.1(ALK*F1174L)Heno/Alktm1.1(ALK*F1174L)Heno
Tmem163Tg(ACTB-cre)2Mrt/Tmem163+
Genetic
Background		 involves: 129X1/SvJ * C57BL/6 * C57BL/6N * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Alktm1.1(ALK*F1174L)Heno mutation (0 available); any Alk mutation (62 available)
Tmem163Tg(ACTB-cre)2Mrt mutation (3 available); any Tmem163 mutation (35 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal stellate ganglion morphology ( J:294092 )
• size of the sympathetic ganglia (stellate ganglia) is larger at E13.5

neoplasm
neoplasm ( J:294092 )
N
• mice show no overt signs of tumorigenesis




Genotype
MGI:6476976
cn5
Allelic
Composition		 Alktm1.1(ALK*F1174L)Heno/Alktm1.1(ALK*F1174L)Heno
Tg(Mpz-cre)94Imeg/0
Genetic
Background		 involves: 129X1/SvJ * C57BL/6 * C57BL/6N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Alktm1.1(ALK*F1174L)Heno mutation (0 available); any Alk mutation (62 available)
Tg(Mpz-cre)94Imeg mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal sympathetic ganglion morphology ( J:294092 )
• increase in proliferation of sympathetic ganglion progenitors
enlarged superior cervical ganglion ( J:294092 )
• size of the sympathetic ganglia (superior cervical ganglia) is larger at E13.5
• increase in cell numbers in superior cervical ganglia

neoplasm
neoplasm ( J:294092 )
N
• mice show no overt signs of tumorigenesis




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory