All Phenotypes Tg(Myh6-cre)#Cya MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tg(Myh6-cre)#Cya
transgene insertion, Cyagen Biosciences
MGI:6470610

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Gt(ROSA)26Sor^{em1(CAG-Zfas1)Cya}/Gt(ROSA)26Sor⁺ Tg(Myh6-cre)#Cya/0	involves: C57BL/6J	MGI:6470625

Allelic Composition	Gt(ROSA)26Sor^{em1(CAG-Zfas1)Cya}/Gt(ROSA)26Sor⁺ Tg(Myh6-cre)#Cya/0
Genetic Background	involves: C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{em1(CAG-Zfas1)Cya} mutation (0 available); any Gt(ROSA)26Sor mutation (1046 available)
Tg(Myh6-cre)#Cya mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

dilated heart left ventricle ( J:294533 )

• increased left ventricular internal dimension at end-diastole (LVIDd) and at systole (LVIDs)

decreased cardiac muscle contractility ( J:294533 )

• decreased ejection fraction (EF) and fractional shortening (FS)

cellular

increased cardiomyocyte apoptosis ( J:294533 )

homeostasis/metabolism

abnormal calcium ion homeostasis ( J:294533 )

• increased resting intracellular Ca²⁺ level in cardiomyocytes

muscle

decreased cardiac muscle contractility ( J:294533 )

• decreased ejection fraction (EF) and fractional shortening (FS)

increased cardiomyocyte apoptosis ( J:294533 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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