Phenotypes associated with this allele

• Allele Symbol: Gt(ROSA)26Sor^{em1(CAG-Zfas1)Cya}
• Allele Name: endonuclease-mediated mutation 1, Cyagen Biosciences
• Allele ID: MGI:6470593
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Gt(ROSA)26Sor^em1(CAG-Zfas1)Cya/Gt(ROSA)26Sor^+ Tg(Myh6-cre)#Cya/0	involves: C57BL/6J	MGI:6470625

Genotype
MGI:6470625

cn1

• Allelic Composition: Gt(ROSA)26Sor^{em1(CAG-Zfas1)Cya}/Gt(ROSA)26Sor⁺; Tg(Myh6-cre)#Cya/0
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

dilated heart left ventricle ( J:294533 )

• increased left ventricular internal dimension at end-diastole (LVIDd) and at systole (LVIDs)

decreased cardiac muscle contractility ( J:294533 )

• decreased ejection fraction (EF) and fractional shortening (FS)

increased cardiomyocyte apoptosis ( J:294533 )

cellular

increased cardiomyocyte apoptosis ( J:294533 )

homeostasis/metabolism

abnormal calcium ion homeostasis ( J:294533 )

• increased resting intracellular Ca²⁺ level in cardiomyocytes

muscle

decreased cardiac muscle contractility ( J:294533 )

• decreased ejection fraction (EF) and fractional shortening (FS)

increased cardiomyocyte apoptosis ( J:294533 )