About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rab35tm1.1Vha
targeted mutation 1.1, Volker Haucke
MGI:6467522
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Rab35tm1.1Vha/Rab35tm1.1Vha
Tg(CAG-cre/Esr1*)5Amc/0 		involves: 129/Sv * 129S4/SvJaeSor * C57BL/6J * C57BL/6 * CBA MGI:6467551
cn2
 		Rab35tm1.1Vha/Rab35tm1.1Vha
Tg(Mpz-cre)26Mes/0 		involves: 129/Sv * 129S4/SvJaeSor * C57BL/6J * FVB/NTac MGI:6467549


Genotype
MGI:6467551
cn1
Allelic
Composition		 Rab35tm1.1Vha/Rab35tm1.1Vha
Tg(CAG-cre/Esr1*)5Amc/0
Genetic
Background		 involves: 129/Sv * 129S4/SvJaeSor * C57BL/6J * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rab35tm1.1Vha mutation (0 available); any Rab35 mutation (19 available)
Tg(CAG-cre/Esr1*)5Amc mutation (11 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
increased astrocyte size ( J:294178 )
• larger in vitro cultured astrocytes after tamoxifen induction

cellular
increased astrocyte size ( J:294178 )
• larger in vitro cultured astrocytes after tamoxifen induction




Genotype
MGI:6467549
cn2
Allelic
Composition		 Rab35tm1.1Vha/Rab35tm1.1Vha
Tg(Mpz-cre)26Mes/0
Genetic
Background		 involves: 129/Sv * 129S4/SvJaeSor * C57BL/6J * FVB/NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rab35tm1.1Vha mutation (0 available); any Rab35 mutation (19 available)
Tg(Mpz-cre)26Mes mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:294178 )
N
• born at normal Mendelian ratio

nervous system
decreased myelin sheath thickness ( J:294178 )
• normal thickness in sciatic nerves and normal number of myelinated axons at age P20, P30 and P90
• reduced thickness in larger sciatic nerves (>5 micrometer diameter) at age P90
tomacula ( J:294178 )
• in sciatic nerves at age P90




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory