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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rab35tm1.1Vha
targeted mutation 1.1, Volker Haucke
MGI:6467522
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Rab35tm1.1Vha/Rab35tm1.1Vha
Tg(CAG-cre/Esr1*)5Amc/0 		involves: 129/Sv * 129S4/SvJaeSor * C57BL/6J * C57BL/6 * CBA MGI:6467551
cn2
 		Rab35tm1.1Vha/Rab35tm1.1Vha
Tg(Mpz-cre)26Mes/0 		involves: 129/Sv * 129S4/SvJaeSor * C57BL/6J * FVB/NTac MGI:6467549


Genotype
MGI:6467551
cn1
Allelic
Composition		 Rab35tm1.1Vha/Rab35tm1.1Vha
Tg(CAG-cre/Esr1*)5Amc/0
Genetic
Background		 involves: 129/Sv * 129S4/SvJaeSor * C57BL/6J * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rab35tm1.1Vha mutation (0 available); any Rab35 mutation (19 available)
Tg(CAG-cre/Esr1*)5Amc mutation (11 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
increased astrocyte size ( J:294178 )
• larger in vitro cultured astrocytes after tamoxifen induction

cellular
increased astrocyte size ( J:294178 )
• larger in vitro cultured astrocytes after tamoxifen induction




Genotype
MGI:6467549
cn2
Allelic
Composition		 Rab35tm1.1Vha/Rab35tm1.1Vha
Tg(Mpz-cre)26Mes/0
Genetic
Background		 involves: 129/Sv * 129S4/SvJaeSor * C57BL/6J * FVB/NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rab35tm1.1Vha mutation (0 available); any Rab35 mutation (19 available)
Tg(Mpz-cre)26Mes mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:294178 )
N
• born at normal Mendelian ratio

nervous system
decreased myelin sheath thickness ( J:294178 )
• normal thickness in sciatic nerves and normal number of myelinated axons at age P20, P30 and P90
• reduced thickness in larger sciatic nerves (>5 micrometer diameter) at age P90
tomacula ( J:294178 )
• in sciatic nerves at age P90




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory