Rab35^tm1.1Vha
Targeted Allele Detail

Summary

• Symbol: Rab35^tm1.1Vha
• Name: RAB35, member RAS oncogene family; targeted mutation 1.1, Volker Haucke
• MGI ID: MGI:6467522
• Synonyms: Rab35^flox
• Gene: Rab35 Location: Chr5:115769953-115785217 bp, + strand Genetic Position: Chr5, 56.1 cM
• Alliance: Rab35^tm1.1Vha page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:294178
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: (129/Sv x C57BL/6J)F1

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: Using BAC clone RP23-192F6, a loxP site was inserted into intron 1 and a FRT site flanked neomycin resistance gene cassette and a second loxP site into intron 3. The neo cassette was removed through subsequent flp-mediated recombination, leaving a conditional-ready allele with exons 2 and 3 floxed. (J:294178)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rab35 Mutation: 21 strains or lines available

References

• Original: J:294178 Sawade L, et al., Rab35-regulated lipid turnover by myotubularins represses mTORC1 activity and controls myelin growth. Nat Commun. 2020 Jun 5;11(1):2835
• All: 1 reference(s)