Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sppl3em1Pomz mutation
(0 available);
any
Sppl3 mutation
(75 available)
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mortality/aging
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• although mice are born in expected Mendelian ratios, ~15 of mice die shortly after birth
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• nearly all mice are dead by weaning age
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ncr1tm1.1(icre)Viv mutation
(1 available);
any
Ncr1 mutation
(39 available)
Sppl3em1Pomz mutation
(0 available);
any
Sppl3 mutation
(75 available)
Sppl3tm1Itl mutation
(0 available);
any
Sppl3 mutation
(75 available)
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mortality/aging
N |
• mice are born in Mendelian ratios and survive without any overt phenotype
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immune system
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• mice show a defect in NK cell maturation with a 1.8-fold reduction of CD27+CD11b+ NK cells in the bone marrow and a 3-fold loss of CD27+CD11b+ NK cells in spleen
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• mice show a 1.4-fold increase in the number of immature CD27+CD11b- NK cells in bone marrow but no significant change in spleen
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• mice exhibit reduced numbers of peripheral NK cells with a 2.9-fold reduction of NK cell number in spleen
• however, NK cell number is normal in the bone marrow
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• mice show a 6-fold reduction of mature CD27-CD11b+ NK cells in spleen, and 3-fold loss of CD27-CD11b+ NK cells in the bone marrow
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hematopoietic system
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• mice show a defect in NK cell maturation with a 1.8-fold reduction of CD27+CD11b+ NK cells in the bone marrow and a 3-fold loss of CD27+CD11b+ NK cells in spleen
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• mice show a 1.4-fold increase in the number of immature CD27+CD11b- NK cells in bone marrow but no significant change in spleen
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• mice exhibit reduced numbers of peripheral NK cells with a 2.9-fold reduction of NK cell number in spleen
• however, NK cell number is normal in the bone marrow
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• mice show a 6-fold reduction of mature CD27-CD11b+ NK cells in spleen, and 3-fold loss of CD27-CD11b+ NK cells in the bone marrow
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