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Allele Symbol Allele Name Allele ID |
Dynlrb1tm1c(EUCOMM)Wtsi targeted mutation 1c, Wellcome Trust Sanger Institute MGI:6466548 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• after infection with Adenovirus 5 (Ad5) expressing a Cre-GFP, dorsal root ganglia (DRG) neurons transduced for 96 h in culture show impaired axonal retrograde transport of acidic organelles, including lysosomes, late endosomes and autophagosomes, both in terms of velocity of individual carriers and the overall fraction of moving carriers
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• adult mice show an abnormal clenched hind-limb phenotype when suspended by the tail
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• adult mice exhibit impaired proprioception
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• adult mice are unable to balance themselves on an accelerating rotarod
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• adult mice show an uncoordinated walking pattern with abdomen posture close to the ground and display an abnormal walking pattern in the catwalk
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• adult mice exhibit reduced speed and less distance traveled than wild type controls in the open field
• however, basal motor activity is normal
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| N |
• mice show no significant alterations in neuromuscular junction size or numbers and in total (Tuj1 positive) or nociceptive (CGRP positive) skin innervation
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• the number of proprioceptive NFH-positive neurons in DRG ganglia is significantly decreased
• however, the number of CGRP-positive nociceptive neurons is normal
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/14/2024 MGI 6.23 |
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