Phenotypes associated with this allele

• Allele Symbol: Plod2^em1Kaat
• Allele Name: endonuclease-mediated mutation 1, Atsushi Kasamatsu
• Allele ID: MGI:6460419
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Plod2^em1Kaat/Plod2^em1Kaat	involves: C57BL/6 * DBA/2	MGI:6460420

Genotype
MGI:6460420

hm1

• Allelic Composition: Plod2^em1Kaat/Plod2^em1Kaat
• Genetic Background: involves: C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:291131 )

• die between E10.5 and E11.5

cardiovascular system

abnormal heart ventricle morphology ( J:291131 )

• insufficient wall in the common ventricle at E10.5

• loosely packed cellular structure at E10.5

• changes in structure suggest heart failure

thin ventricular wall ( J:291131 )

• at E10.5

cellular

increased apoptosis ( J:291131 )

• expression analysis indicates increased apoptosis in embryonic hearts

increased endoplasmic reticulum stress ( J:291131 )

• expression analysis indicates increased ER stress in embryos

embryo

decreased embryo size ( J:291131 )

• obviously smaller than control littermates by E10.5

growth/size/body

decreased embryo size ( J:291131 )

• obviously smaller than control littermates by E10.5