Plod2^em1Kaat
Endonuclease-mediated Allele Detail

Summary

• Symbol: Plod2^em1Kaat
• Name: procollagen lysine, 2-oxoglutarate 5-dioxygenase 2; endonuclease-mediated mutation 1, Atsushi Kasamatsu
• MGI ID: MGI:6460419
• Synonyms: LH2^-
• Gene: Plod2 Location: Chr9:92424276-92490481 bp, + strand Genetic Position: Chr9, 48.4 cM
• Alliance: Plod2^em1Kaat page

Mutation origin

• Strain of Origin: B6D2F1

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/cas9 mediated recombination created a 2bp (TC) deletion in exon 3 resulting a frameshift and premature stop codon in the transcript. Immunohistochemical analysis confirmed the absence of protein expression in homozygous embryos. (J:291131)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Plod2 Mutation: 45 strains or lines available

References

• Original: J:291131 Kasamatsu A, et al., Deficiency of lysyl hydroxylase 2 in mice causes systemic endoplasmic reticulum stress leading to early embryonic lethality. Biochem Biophys Res Commun. 2019 May 7;512(3):486-491
• All: 2 reference(s)