Phenotypes associated with this allele

• Allele Symbol: Prdx5^tm1Dsle
• Allele Name: targeted mutation 1, Dong-Seok Lee
• Allele ID: MGI:6458912
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Prdx5^tm1Dsle/Prdx5^tm1Dsle	involves: C57BL/6	MGI:6458914

Genotype
MGI:6458914

hm1

• Allelic Composition: Prdx5^tm1Dsle/Prdx5^tm1Dsle
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:294801 )

N • mice fed a high-fat diet exhibit normal serum triglyceride, total cholesterol, and HDL-cholesterol levels

increased susceptibility to diet-induced obesity ( J:294801 )

• in mice fed a high-fat diet despite normal food intake

increased circulating insulin level ( J:294801 )

• in mice fed a high-fat diet

increased circulating leptin level ( J:294801 )

• in mice fed a high-fat diet

impaired glucose tolerance ( J:294801 )

• in mice fed a high-fat diet

insulin resistance ( J:294801 )

• in mice fed a high-fat diet

increased liver triglyceride level ( J:294801 )

• in mice fed a high-fat diet

growth/size/body

increased body weight ( J:294801 )

• in mice fed a high-fat diet despite normal food intake

• however, mice fed standard chow exhibit normal weight

increased susceptibility to diet-induced obesity ( J:294801 )

• in mice fed a high-fat diet despite normal food intake

increased liver weight ( J:294801 )

• in mice fed a high-fat diet

liver/biliary system

increased liver weight ( J:294801 )

• in mice fed a high-fat diet

increased liver triglyceride level ( J:294801 )

• in mice fed a high-fat diet

increased susceptibility to diet-induced hepatic steatosis ( J:294801 )

• larger, greasier liver in mice fed a high-fat diet

adipose tissue

abnormal epididymal fat pad morphology ( J:294801 )

• in mice fed a high-fat diet

• however, mice fed standard chow exhibit normal fat pads

abnormal inguinal fat pad morphology ( J:294801 )

• in mice fed a high-fat diet

• however, mice fed standard chow exhibit normal fat pads

behavior/neurological

behavior/neurological phenotype ( J:294801 )

N • mice exhibit normal food intake whether fed standard chow or a high-fat diet

cellular

oxidative stress ( J:294801 )

• in the white adipose tissue of mice fed a high-fat diet