About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Smdt1tm1c(EUCOMM)Wtsi
targeted mutation 1c, Wellcome Trust Sanger Institute
MGI:6457374
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Lama2tm1Eeng/Lama2tm1Eeng
Smdt1tm1c(EUCOMM)Wtsi/Smdt1tm1c(EUCOMM)Wtsi
Tg(Ckmm-cre)5Khn/0 		involves: 129S1/Sv * 129S4/SvJae * C57BL/6N * FVB MGI:6458049
cn2
 		Smdt1tm1c(EUCOMM)Wtsi/Smdt1tm1c(EUCOMM)Wtsi
Tg(Ckmm-cre)5Khn/0 		involves: 129S4/SvJae * C57BL/6N * FVB MGI:6458047


Genotype
MGI:6458049
cn1
Allelic
Composition		 Lama2tm1Eeng/Lama2tm1Eeng
Smdt1tm1c(EUCOMM)Wtsi/Smdt1tm1c(EUCOMM)Wtsi
Tg(Ckmm-cre)5Khn/0
Genetic
Background		 involves: 129S1/Sv * 129S4/SvJae * C57BL/6N * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lama2tm1Eeng mutation (2 available); any Lama2 mutation (178 available)
Smdt1tm1c(EUCOMM)Wtsi mutation (0 available); any Smdt1 mutation (10 available)
Tg(Ckmm-cre)5Khn mutation (5 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:287405 )
• as in Lama2tm1Eeng homozygotes

behavior/neurological
decreased grip strength ( J:287405 )
• as in Lama2tm1Eeng homozygotes

cellular
abnormal mitochondrial physiology ( J:287405 )
• increase in mitochondrial calcium in skeletal muscle fiber as in Lama2tm1Eeng homozygotes




Genotype
MGI:6458047
cn2
Allelic
Composition		 Smdt1tm1c(EUCOMM)Wtsi/Smdt1tm1c(EUCOMM)Wtsi
Tg(Ckmm-cre)5Khn/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6N * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smdt1tm1c(EUCOMM)Wtsi mutation (0 available); any Smdt1 mutation (10 available)
Tg(Ckmm-cre)5Khn mutation (5 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal mitochondrial physiology ( J:287405 )
• slight decrease in mitochondrial calcium in skeletal muscle fiber

growth/size/body
growth/size/body region phenotype ( J:287405 )
N
• mice exhibit normal body weight

behavior/neurological
behavior/neurological phenotype ( J:287405 )
N
• mice exhibit normal grip strength




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory