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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Smdt1tm1c(EUCOMM)Wtsi
targeted mutation 1c, Wellcome Trust Sanger Institute
MGI:6457374
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Lama2tm1Eeng/Lama2tm1Eeng
Smdt1tm1c(EUCOMM)Wtsi/Smdt1tm1c(EUCOMM)Wtsi
Tg(Ckmm-cre)5Khn/0 		involves: 129S1/Sv * 129S4/SvJae * C57BL/6N * FVB MGI:6458049
cn2
 		Smdt1tm1c(EUCOMM)Wtsi/Smdt1tm1c(EUCOMM)Wtsi
Tg(Ckmm-cre)5Khn/0 		involves: 129S4/SvJae * C57BL/6N * FVB MGI:6458047


Genotype
MGI:6458049
cn1
Allelic
Composition		 Lama2tm1Eeng/Lama2tm1Eeng
Smdt1tm1c(EUCOMM)Wtsi/Smdt1tm1c(EUCOMM)Wtsi
Tg(Ckmm-cre)5Khn/0
Genetic
Background		 involves: 129S1/Sv * 129S4/SvJae * C57BL/6N * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lama2tm1Eeng mutation (2 available); any Lama2 mutation (177 available)
Smdt1tm1c(EUCOMM)Wtsi mutation (0 available); any Smdt1 mutation (11 available)
Tg(Ckmm-cre)5Khn mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:287405 )
• as in Lama2tm1Eeng homozygotes

behavior/neurological
decreased grip strength ( J:287405 )
• as in Lama2tm1Eeng homozygotes

cellular
abnormal mitochondrial physiology ( J:287405 )
• increase in mitochondrial calcium in skeletal muscle fiber as in Lama2tm1Eeng homozygotes




Genotype
MGI:6458047
cn2
Allelic
Composition		 Smdt1tm1c(EUCOMM)Wtsi/Smdt1tm1c(EUCOMM)Wtsi
Tg(Ckmm-cre)5Khn/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6N * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smdt1tm1c(EUCOMM)Wtsi mutation (0 available); any Smdt1 mutation (11 available)
Tg(Ckmm-cre)5Khn mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal mitochondrial physiology ( J:287405 )
• slight decrease in mitochondrial calcium in skeletal muscle fiber

growth/size/body
growth/size/body region phenotype ( J:287405 )
N
• mice exhibit normal body weight

behavior/neurological
behavior/neurological phenotype ( J:287405 )
N
• mice exhibit normal grip strength




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory