Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Skp1tm1.1Jw mutation
(0 available);
any
Skp1 mutation
(18 available)
Skp1tm1.2Jw mutation
(0 available);
any
Skp1 mutation
(18 available)
Tg(Ddx4-cre)1Dcas mutation
(2 available)
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cellular
reproductive system
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Skp1tm1.1Jw mutation
(0 available);
any
Skp1 mutation
(18 available)
Skp1tm1.2Jw mutation
(0 available);
any
Skp1 mutation
(18 available)
Tg(Ddx4-cre/ERT2)1Dcas mutation
(1 available)
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reproductive system
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• at 4 months in tamoxifen-treated mice despite being present at 2 months
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• precocious chromosomal desynapsis in the female and male germ cells of tamoxifen-treated mice
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• misalignment of chromosomes in the oocytes of tamoxifen treated mice
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• progressive in tamoxifen-treated mice
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• severe in tamoxifen-treated mice with absent metaphase spermatocytes
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• absent metaphase spermatocytes and postmeiotic spermatids in tamoxifen-treated mice
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• precocious chromosomal desynapsis and pachytene exit leading to absent metaphase spermatocytes in tamoxifen-treated mice
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• in tamoxifen-treated mice
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homeostasis/metabolism
endocrine/exocrine glands
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• progressive in tamoxifen-treated mice
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cellular
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• at 4 months in tamoxifen-treated mice despite being present at 2 months
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• absent metaphase spermatocytes and postmeiotic spermatids in tamoxifen-treated mice
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• precocious chromosomal desynapsis in the female and male germ cells of tamoxifen-treated mice
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• misalignment of chromosomes in the oocytes of tamoxifen treated mice
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• precocious chromosomal desynapsis and pachytene exit leading to absent metaphase spermatocytes in tamoxifen-treated mice
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• impaired meiotic recombination in spermatocytes and oocytes of tamoxifen-treated mice
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• in vitro fertilized oocytes fail to sustain preimplantation embryonic development
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