Phenotypes associated with this allele

• Allele Symbol: Kat8^tm1.2Avo
• Allele Name: targeted mutation 1.2, Anne K Voss
• Allele ID: MGI:6455412
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Kat8^tm1.2Avo/Kat8^tm1.2Avo Tg(Nes-cre)1Kln/0	involves: C57BL/6 * SJL	MGI:6455413

Genotype
MGI:6455413

cn1

• Allelic Composition: Kat8^tm1.2Avo/Kat8^tm1.2Avo; Tg(Nes-cre)1Kln/0
• Genetic Background: involves: C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality during fetal growth through weaning, incomplete penetrance ( J:291094 )

• nearly all mice die between E16.5 and birth

postnatal lethality, complete penetrance ( J:291094 )

• no mice are present at 3 weeks after birth

nervous system

abnormal brain vasculature morphology ( J:291094 )

• mice exhibit dilated brain microvessels and thinning of extracellular matrix with rare collapse and pericyte detachment compared with wild-type mice

enlarged lateral ventricles ( J:291094 )

abnormal cerebral cortex morphology ( J:291094 )

• severely disorganized at E16.5

• however, the cortex is normal at E14.5

abnormal embryonic/fetal subventricular zone morphology ( J:291094 )

• disorganized and hemorrhaging in the ganglionic eminence with extensive cell death

• however, no significant cell death is observed in the cortex at E14.5

cardiovascular system

abnormal brain vasculature morphology ( J:291094 )

• mice exhibit dilated brain microvessels and thinning of extracellular matrix with rare collapse and pericyte detachment compared with wild-type mice

abnormal pericyte morphology ( J:291094 )

• pericyte detachment from brain microvessels

• however, total number of pericytes are normal

hemorrhage ( J:291094 )

• in all mice at E14.5, in brain parenchyma

• most severe in the region of the ganglionic eminence

homeostasis/metabolism

increased fatty acids level ( J:291094 )

• in neurospheres