All Phenotypes Nubp2<tm1c(EUCOMM)Hmgu> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Nubp2^{tm1c(EUCOMM)Hmgu}/Nubp2^{tm1c(EUCOMM)Hmgu} Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo}/Gt(ROSA)26Sor⁺ H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺ Tg(Wnt1-GAL4)11Rth/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA/J	MGI:6452819
cn2	Nubp2^{tm1c(EUCOMM)Hmgu}/Nubp2^{tm1c(EUCOMM)Hmgu} H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺ Tg(Wnt1-GAL4)11Rth/0	involves: C57BL/6	MGI:6450919

Allelic Composition	Nubp2^{tm1c(EUCOMM)Hmgu}/Nubp2^{tm1c(EUCOMM)Hmgu} Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo}/Gt(ROSA)26Sor⁺ H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺ Tg(Wnt1-GAL4)11Rth/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo} mutation (10 available); any Gt(ROSA)26Sor mutation (944 available)
H2az2^{Tg(Wnt1-cre)11Rth} mutation (2 available); any H2az2 mutation (26 available)
Nubp2^{tm1c(EUCOMM)Hmgu} mutation (0 available); any Nubp2 mutation (17 available)
Tg(Wnt1-GAL4)11Rth mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

increased cranial neural crest cell apoptosis ( J:284772 )

• reduced +GFP craniofacial neural crest cells in nasal prominences and pharyngeal arches due to increased apoptosis between E9.5 and E10.5

cellular

increased cranial neural crest cell apoptosis ( J:284772 )

• reduced +GFP craniofacial neural crest cells in nasal prominences and pharyngeal arches due to increased apoptosis between E9.5 and E10.5

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

craniofacial

small frontonasal prominence ( J:284772 )

• at E15.5

small mandibular prominence ( J:284772 )

• at E15.5

small maxillary prominence ( J:284772 )

• at E15.5

absent nasal capsule ( J:284772 )

abnormal face development ( J:284772 )

• undersized facial primordia at E10.5

nasal septum cartilage hypoplasia ( J:284772 )

• severe

abnormal olfactory epithelium morphology ( J:284772 )

• olfactory epithelium is continuous with the oral cavity

midline facial cleft ( J:284772 )

• at E15.5

growth/size/body

absent nasal capsule ( J:284772 )

abnormal face development ( J:284772 )

• undersized facial primordia at E10.5

nasal septum cartilage hypoplasia ( J:284772 )

• severe

abnormal olfactory epithelium morphology ( J:284772 )

• olfactory epithelium is continuous with the oral cavity

midline facial cleft ( J:284772 )

• at E15.5

abnormal head mesenchyme morphology ( J:284772 )

• craniofacial mesenchyme exhibit a slight increase in average cilia per cell compared with control mice

• however, there is no difference in centriole number

embryo

abnormal head mesenchyme morphology ( J:284772 )

• craniofacial mesenchyme exhibit a slight increase in average cilia per cell compared with control mice

• however, there is no difference in centriole number

digestive/alimentary system

abnormal stomodeum morphology ( J:284772 )

• olfactory epithelium is continuous with the oral cavity

nervous system

abnormal brain morphology ( J:284772 )

• brain is shifted rostrally

respiratory system

absent nasal capsule ( J:284772 )

nasal septum cartilage hypoplasia ( J:284772 )

• severe

abnormal olfactory epithelium morphology ( J:284772 )

• olfactory epithelium is continuous with the oral cavity

skeleton

absent nasal capsule ( J:284772 )

nasal septum cartilage hypoplasia ( J:284772 )

• severe

taste/olfaction

abnormal olfactory epithelium morphology ( J:284772 )

• olfactory epithelium is continuous with the oral cavity

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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