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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Clstn3tm1c(EUCOMM)Hmgu
targeted mutation 1c, Helmholtz Zentrum Muenchen GmbH
MGI:6449227
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Clstn3tm1c(EUCOMM)Hmgu/Clstn3tm1c(EUCOMM)Hmgu
Lyz2tm1(cre)Ifo/Lyz2+ 		involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N * SJL MGI:6454084
cn2
 		Clstn3tm1c(EUCOMM)Hmgu/Clstn3tm1c(EUCOMM)Hmgu
Tg(Syn1-cre)671Jxm/0 		involves: C57BL/6 * C57BL/6N * CBA * SJL MGI:6454088
cn3
 		Clstn3tm1c(EUCOMM)Hmgu/Clstn3tm1c(EUCOMM)Hmgu
Tg(BGLAP-cre)1Clem/0 		involves: C57BL/6 * C57BL/6N * FVB/NJ * SJL MGI:6454085
cn4
 		Clstn3tm1c(EUCOMM)Hmgu/Clstn3tm1c(EUCOMM)Hmgu
Tg(Dbh-cre)KH212Gsat/0 		involves: C57BL/6 * C57BL/6N * FVB/NTac * SJL MGI:6454087


Genotype
MGI:6454084
cn1
Allelic
Composition		 Clstn3tm1c(EUCOMM)Hmgu/Clstn3tm1c(EUCOMM)Hmgu
Lyz2tm1(cre)Ifo/Lyz2+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Clstn3tm1c(EUCOMM)Hmgu mutation (0 available); any Clstn3 mutation (65 available)
Lyz2tm1(cre)Ifo mutation (14 available); any Lyz2 mutation (41 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
limbs/digits/tail
limbs/digits/tail phenotype ( J:293885 )
N
• normal bone morphology




Genotype
MGI:6454088
cn2
Allelic
Composition		 Clstn3tm1c(EUCOMM)Hmgu/Clstn3tm1c(EUCOMM)Hmgu
Tg(Syn1-cre)671Jxm/0
Genetic
Background		 involves: C57BL/6 * C57BL/6N * CBA * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Clstn3tm1c(EUCOMM)Hmgu mutation (0 available); any Clstn3 mutation (65 available)
Tg(Syn1-cre)671Jxm mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
adipose tissue
decreased bone marrow adipose tissue amount ( J:293885 )
• reduced bone marrow volume

growth/size/body
decreased body mass index ( J:293885 )
• from age 6 weeks on normal chow

limbs/digits/tail
limbs/digits/tail phenotype ( J:293885 )
N
• normal volume fraction, thickness, number, and separation of trabecular bone in distal metaphysis

skeleton
decreased bone marrow adipose tissue amount ( J:293885 )
• reduced bone marrow volume
decreased compact bone mass ( J:293885 )
• at distal metaphysis and midshaft regions of femur
• normal cortical bone thickness




Genotype
MGI:6454085
cn3
Allelic
Composition		 Clstn3tm1c(EUCOMM)Hmgu/Clstn3tm1c(EUCOMM)Hmgu
Tg(BGLAP-cre)1Clem/0
Genetic
Background		 involves: C57BL/6 * C57BL/6N * FVB/NJ * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Clstn3tm1c(EUCOMM)Hmgu mutation (0 available); any Clstn3 mutation (65 available)
Tg(BGLAP-cre)1Clem mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
limbs/digits/tail
limbs/digits/tail phenotype ( J:293885 )
N
• normal bone morphology




Genotype
MGI:6454087
cn4
Allelic
Composition		 Clstn3tm1c(EUCOMM)Hmgu/Clstn3tm1c(EUCOMM)Hmgu
Tg(Dbh-cre)KH212Gsat/0
Genetic
Background		 involves: C57BL/6 * C57BL/6N * FVB/NTac * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Clstn3tm1c(EUCOMM)Hmgu mutation (0 available); any Clstn3 mutation (65 available)
Tg(Dbh-cre)KH212Gsat mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
growth/size/body region phenotype ( J:293885 )
N
• normal body weight

limbs/digits/tail
limbs/digits/tail phenotype ( J:293885 )
N
• normal bone morphology




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Send questions and comments to User Support. 		last database update
05/14/2024
MGI 6.23 		The Jackson Laboratory