Phenotypes associated with this allele

• Allele Symbol: Rhbdf1^em1Mvw
• Allele Name: endonuclease-mediated mutation 1, Michael Wiles
• Allele ID: MGI:6446985
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rhbdf1^em1Mvw/Rhbdf1^em1Mvw	C57BL/6J-Rhbdf1^em1Mvw/Mvw	MGI:6449089
cx2	Rhbdf1^em1Mvw/Rhbdf1^em1Mvw Rhbdf2^tm1a(KOMP)Wtsi/Rhbdf2^tm1a(KOMP)Wtsi	B6.Cg-Rhbdf1^em1Mvw Rhbdf2^tm1a(KOMP)Wtsi/Mvw	MGI:6449217

Genotype
MGI:6449089

hm1

• Allelic Composition: Rhbdf1^em1Mvw/Rhbdf1^em1Mvw
• Genetic Background: C57BL/6J-Rhbdf1^em1Mvw/Mvw

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

normal phenotype

no abnormal phenotype detected ( J:291556 )

• While null alleles of this gene cause phenotypic abnormalities, homozygotes for this deletion of exon 2 and 3 have a normal phenotype due to alternative transcripts

Genotype
MGI:6449217

cx2

• Allelic Composition: Rhbdf1^em1Mvw/Rhbdf1^em1Mvw; Rhbdf2^{tm1a(KOMP)Wtsi}/Rhbdf2^{tm1a(KOMP)Wtsi}
• Genetic Background: B6.Cg-Rhbdf1^em1Mvw Rhbdf2^{tm1a(KOMP)Wtsi}/Mvw

integument

waved hair ( J:291556 )

vision/eye

eyelids open at birth ( J:291556 )

cardiovascular system

cardiovascular system phenotype ( J:291556 )

N • although double mutants for true null alleles are subviable with brain and heart defects, these mice do not have those defects