Analysis Tools|
Allele Symbol Allele Name Allele ID |
Fis1tm1.1Itl targeted mutation 1.1, inGenious Targeting Laboratory MGI:6444618 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• increased GFP-LC3 puncta containing mitochondria in the soleus of sedentary mice
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• increased GFP-LC3 puncta containing mitochondria in the soleus of sedentary mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• following 3 consecutive days of exercise to exhaustion, mice exhibit increased body temperature, increased plasma cytokines (IL-6, IL-12p40, IL-13, KC, RANTES and IFNbeta), disorganized Z-band in soleus muscle, and delayed onset muscle ultrastructure change in soleus muscle compared with wild-type mice
• however, plasma cytokine levels return to normal after exercise exhaustion
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• in mice exercised to exhausting on consecutive days
• however, plasma cytokine levels return to normal after exercise exhaustion
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• in mice exercised to exhausting on consecutive days
• however, plasma cytokine levels return to normal after exercise exhaustion
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• in mice exercised to exhausting on consecutive days
• however, plasma cytokine levels return to normal after exercise exhaustion
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• in mice exercised to exhausting on consecutive days
• however, plasma cytokine levels return to normal after exercise exhaustion
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• following 3 consecutive days of exercise to exhaustion
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• loss of cristae and low matric density
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• prior to and after exercise
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• impaired respiratory chain function in slow muscle with reduced Complex I protein levels
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• in the soleus of mice exercised to exhausting on consecutive days
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• delayed onset muscle ultrastructure change in the soleus of mice exercised to exhausting on consecutive days
• however, there are no ultrastructure changes in the gastrocnemius following exercise
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• following 3 consecutive days of exercise to exhaustion, mice exhibit increased body temperature, increased plasma cytokines (IL-6, IL-12p40, IL-13, KC, RANTES and IFNbeta), disorganized Z-band in soleus muscle, and delayed onset muscle ultrastructure change in soleus muscle compared with wild-type mice
• however, plasma cytokine levels return to normal after exercise exhaustion
|
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• in mice exercised to exhausting on consecutive days
• however, plasma cytokine levels return to normal after exercise exhaustion
|
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• in mice exercised to exhausting on consecutive days
• however, plasma cytokine levels return to normal after exercise exhaustion
|
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• in mice exercised to exhausting on consecutive days
• however, plasma cytokine levels return to normal after exercise exhaustion
|
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• in mice exercised to exhausting on consecutive days
• however, plasma cytokine levels return to normal after exercise exhaustion
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 09/30/2025 MGI 6.24 |
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