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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Gpr35em2Niess
endonuclease-mediated mutation 2, Jan Hendrik Niess
MGI:6436881
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Gpr35em2Niess/Gpr35em2Niess
Cx3cr1tm2.1(cre/ERT2)Litt/Cx3cr1+
involves: 129P2/OlaHsd * C57BL/6N MGI:6502846


Genotype
MGI:6502846
cn1
Allelic
Composition
Gpr35em2Niess/Gpr35em2Niess
Cx3cr1tm2.1(cre/ERT2)Litt/Cx3cr1+
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cx3cr1tm2.1(cre/ERT2)Litt mutation (1 available); any Cx3cr1 mutation (45 available)
Gpr35em2Niess mutation (0 available); any Gpr35 mutation (32 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
digestive/alimentary system
• in mice treated with tamoxifen and DSS
• however, treatment with TNF attenuates exacerbated DSS-induced colon reduction
• in mice treated with tamoxifen and DSS with increased body weight loss, disease activity scores, and enteroscopic and histological colitis scores, and reduced colon length that are not responsive to LPA treatment
• increased inflammation is not associated with higher macrophage infiltration into the colonic lamina prioria in mice treated with tamoxifen and DSS
• however, treatment with TNF attenuates exacerbated DSS-induced colitis

growth/size/body
• in mice treated with tamoxifen and DSS
• however, treatment with TNF attenuates exacerbated DSS-induced weight loss

immune system
• in mice treated with tamoxifen and DSS with increased body weight loss, disease activity scores, and enteroscopic and histological colitis scores, and reduced colon length that are not responsive to LPA treatment
• increased inflammation is not associated with higher macrophage infiltration into the colonic lamina prioria in mice treated with tamoxifen and DSS
• however, treatment with TNF attenuates exacerbated DSS-induced colitis

homeostasis/metabolism
• lower corticosterone concentrations from the supernatants of colonic explants of mice treated with tamoxifen and DSS
• however, treatment with TNF increases corticosterone concentrations from the supernatants of colonic explants of mice treated with tamoxifen and DSS





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last database update
04/30/2024
MGI 6.23
The Jackson Laboratory