Analysis Tools
cardiovascular system
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IMPC - UCD
(J:211773)
MGI
• by E9.5, many homozygous embryos show abnormal heart morphology, some with cardiac or pericardial edema
(J:374598)
• by E10.5, all embryos recovered intact show grossly abnormal hearts with severe pericardial edema
(J:374598)
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• at E9.5, some homozygous embryos show inappropriate heart looping
(J:374598)
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IMPC - UCD
(J:211773)
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• at E9.5, some homozygous embryos exhibit an enlarged heart
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• by E9.5, some homozygous embryos exhibit pericardial edema
• by E10.5, all embryos recovered intact show severe pericardial edema
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craniofacial
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• at E9.5, a minority of homozygous embryos show branchial arch defects
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• at E9.5, most homozygous embryos exhibit an abnormal head shape, particularly evident in the forebrain
• by E10.5, all embryos recovered intact show an abnormal head shape
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embryo
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IMPC - UCD
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• at E9.5, a minority of homozygous embryos show incomplete turning
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• by E10.5, all embryos recovered intact are developmentally delayed relative to control littermates
• however, all three germ layers are present at E8.5 and properly patterned at E9.5
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• all embryonic phenotypes are more pronounced in older E9.5 homozygous embryos
• by E10.5, all homozygous embryos are grossly abnormal and either dead or dying
• however, at E8.5, nearly all are indistinguishable from control littermates
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• at E9.5, a minority of homozygous embryos show branchial arch defects
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IMPC - UCD
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IMPC - UCD
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• at E10.5, placentas exhibit multiple labyrinth zone defects
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• at E10.5, the Tfeb+ labyrinth trophoblast layer is reduced
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• by E9.5, when dissected intact, most homozygous embryos show abnormal yolk sac morphology
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• at E10.5, chorioallantoic branching is nearly absent, as Gcm1 expression is sparse and remains at the chorioallantoic interface
• however, placentas appear properly developed at E9.5
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• at E10.5, placentas exhibit an abnormal chorioallantoic interface with a reduction in allantoic mesoderm
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growth/size/body
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• at E9.5, some homozygous embryos exhibit an enlarged heart
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• at E9.5, most homozygous embryos exhibit an abnormal head shape, particularly evident in the forebrain
• by E10.5, all embryos recovered intact show an abnormal head shape
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• by E10.5, all embryos recovered intact are developmentally delayed relative to control littermates
• however, all three germ layers are present at E8.5 and properly patterned at E9.5
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homeostasis/metabolism
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• by E9.5, some homozygous embryos exhibit pericardial edema
• by E10.5, all embryos recovered intact show severe pericardial edema
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• by E9.5, some homozygous embryos exhibit cardiac edema
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mortality/aging
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IMPC - UCD
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IMPC - UCD
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• homozygous embryos are present in Mendelian ratios at E8.5 and E9.5; by E10.5, all homozygous embryos are either dead or dying
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nervous system
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IMPC - UCD
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• at E9.5, most homozygous embryos exhibit an abnormal forebrain shape
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vision/eye
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IMPC - UCD
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