| Image |
|
||||
| Caption | Almost all Tgdsem1(IMPC)Mbp/Tgdsem1(IMPC)Mbp (Tgds-/-) E8.5 embryos are indistinguishable from control littermates. By E9.5, most Tgds-/- have an abnormal head shape, particularly noticeable in the forebrain. Many have abnormal hearts, some accompanied by cardiac or pericardial edema. When dissected intact, a majority of Tgds mutants also have abnormal yolk sac morphology. Branchial arch defects and incomplete turning is observed in a minority of E9.5 Tgds mutants. All defects are more pronounced in older E9.5 mutants. By E10.5 all Tgds-/-embryos are grossly abnormal and either dead or dying. Those that were recovered and intact all are delayed, have grossly abnormal hearts with severe pericardial edema and abnormal head shape. | ||||
| Copyright | This image was contributed directly to MGI. Questions regarding this image or these data should be directed to Dr. Kimberly D. Tremblay at kdtrembl@umass.edu. J:374598 | ||||
|
Associated Alleles |
|
||||
|
Associated Genotypes |
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
|
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 12/30/2025 MGI 6.24 |
|
|
|
||
Analysis Tools