All Phenotypes Mapt<tm1.1(MAPT)Tcs> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Mapt^{tm1.1(MAPT)Tcs}
targeted mutation 1.1, Takaomi C Saido
MGI:6414668

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mapt^{tm1.1(MAPT)Tcs}/Mapt^{tm1.1(MAPT)Tcs}	B6.Cg-Mapt^{tm1.1(MAPT)Tcs}	MGI:6414670
cx2	App^tm3.1Tcs/App^tm3.1Tcs Mapt^{tm1.1(MAPT)Tcs}/Mapt^{tm1.1(MAPT)Tcs}	involves: 129S/SvEv * C57BL/6	MGI:6414671

Allelic Composition	Mapt^{tm1.1(MAPT)Tcs}/Mapt^{tm1.1(MAPT)Tcs}
Genetic Background	B6.Cg-Mapt^{tm1.1(MAPT)Tcs}

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapt^{tm1.1(MAPT)Tcs} mutation (4 available); any Mapt mutation (428 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:278451 )

N	• mice do not show accelerated neuroinflammation, neuronal cell death, or brain atrophy

Allelic Composition	App^tm3.1Tcs/App^tm3.1Tcs Mapt^{tm1.1(MAPT)Tcs}/Mapt^{tm1.1(MAPT)Tcs}
Genetic Background	involves: 129S/SvEv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
App^tm3.1Tcs mutation (2 available); any App mutation (89 available)
Mapt^{tm1.1(MAPT)Tcs} mutation (4 available); any Mapt mutation (428 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

increased neuron apoptosis ( J:278451 )

• mice exhibit similar neuronal cell death as in single App^tm3.1Tcs mutants

amyloid beta deposits ( J:278451 )

• mice exhibit similar amyloid pathology as in single App^tm3.1Tcs mutants

CNS inflammation ( J:278451 )

• mice exhibit similar neuroinflammation as in single App^tm3.1Tcs mutants

cellular