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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rad54l2em1(IMPC)Tcp
endonuclease-mediated mutation 1, The Centre for Phenogenomics
MGI:6414504
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Rad54l2em1(IMPC)Tcp/Rad54l2em1(IMPC)Tcp C57BL/6NCrl-Rad54l2em1(IMPC)Tcp/Cmmr MGI:7415043
ht2
 		Rad54l2em1(IMPC)Tcp/Rad54l2+ C57BL/6NCrl-Rad54l2em1(IMPC)Tcp/Cmmr MGI:7415042


Genotype
MGI:7415043
hm1
Allelic
Composition		 Rad54l2em1(IMPC)Tcp/Rad54l2em1(IMPC)Tcp
Genetic
Background		 C57BL/6NCrl-Rad54l2em1(IMPC)Tcp/Cmmr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rad54l2em1(IMPC)Tcp mutation (2 available); any Rad54l2 mutation (177 available)
Data Sources
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Rad54l2em1(IMPC)Tcp/Rad54l2em1(IMPC)Tcp mice exhibit embryonic lethality, with embryos recovered at E3.5 as early blastocysts but not at E7.5. Blastocysts hatch from the zona pellucida and form irregular outgrowths with few adherent trophoblast giant cells.

embryo
decreased trophoblast giant cell number ( J:279207 )
• in vitro outgrowth assays show only a few adherent trophoblast giant cells (TGCs) after 3 days in culture

mortality/aging
embryonic lethality prior to organogenesis, complete penetrance ( J:279207 )
• although early blastocysts are present in expected Mendelian ratios at E3.5, no homozygous embryos or excess resorption sites are observed at E7.5

reproductive system
abnormal embryo implantation ( J:279207 )
• in vitro, blastocysts hatch from the zona pellucida but form irregular outgrowths after 3 days in culture




Genotype
MGI:7415042
ht2
Allelic
Composition		 Rad54l2em1(IMPC)Tcp/Rad54l2+
Genetic
Background		 C57BL/6NCrl-Rad54l2em1(IMPC)Tcp/Cmmr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rad54l2em1(IMPC)Tcp mutation (2 available); any Rad54l2 mutation (177 available)
Data Sources
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
enlarged urinary bladder ( J:211773 )
IMPC - TCP

hematopoietic system
thrombocytosis ( J:211773 )
IMPC - TCP

integument

renal/urinary system

skeleton




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/07/2025
MGI 6.24 		The Jackson Laboratory