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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Slnem1Cyh
endonuclease-mediated mutation 1, Ya-Hui Chi
MGI:6407424
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Slnem1Cyh/Slnem1Cyh Not Specified MGI:6407444
cx2
 		Lmnatm1Stw/Lmnatm1Stw
Slnem1Cyh/Slnem1Cyh 		involves: 129S1/Sv * C57BL/6J MGI:6407445


Genotype
MGI:6407444
hm1
Allelic
Composition		 Slnem1Cyh/Slnem1Cyh
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slnem1Cyh mutation (0 available); any Sln mutation (11 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
growth/size/body region phenotype ( J:284048 )
N
• mice exhibit normal body weight

mortality/aging
mortality/aging ( J:284048 )
N
• mice exhibit normal survival




Genotype
MGI:6407445
cx2
Allelic
Composition		 Lmnatm1Stw/Lmnatm1Stw
Slnem1Cyh/Slnem1Cyh
Genetic
Background		 involves: 129S1/Sv * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lmnatm1Stw mutation (3 available); any Lmna mutation (82 available)
Slnem1Cyh mutation (0 available); any Sln mutation (11 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
decreased body weight ( J:284048 )
• decreased body weight, with body weight similar to single Lmna homozygous mutants

mortality/aging
premature death ( J:284048 )
• mice show increased lethality beginning around 20 days of age and die before 60 days of age
• median lifespan is lower than in single Lmna homozygous mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/14/2024
MGI 6.23 		The Jackson Laboratory