Sln^em1Cyh
Endonuclease-mediated Allele Detail

Summary

• Symbol: Sln^em1Cyh
• Name: sarcolipin; endonuclease-mediated mutation 1, Ya-Hui Chi
• MGI ID: MGI:6407424
• Gene: Sln Location: Chr9:53757535-53761133 bp, + strand Genetic Position: Chr9, 29.24 cM, cytoband C
• Alliance: Sln^em1Cyh page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 technology generated a 31 amino acid deletion in exon 2. Western blot analysis confirmed absence of protein expression. (J:284048)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sln Mutation: 11 strains or lines available

References

• Original: J:284048 Wang WP, et al., Progerin in muscle leads to thermogenic and metabolic defects via impaired calcium homeostasis. Aging Cell. 2020 Feb;19(2):e13090
• All: 1 reference(s)