Phenotypes associated with this allele

• Allele Symbol: Slc38a4^em#Smtb
• Allele Name: endonuclease-mediated mutation, Shogo Matoba
• Allele ID: MGI:6403492
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Slc38a4^em#Smtb/Slc38a4^em#Smtb	C57BL/6NSlc-Slc38a4^em#Ogu	MGI:6403627
ht2	Slc38a4^em#Smtb/Slc38a4^+	C57BL/6NSlc-Slc38a4^em#Ogu	MGI:6403626

Genotype
MGI:6403627

hm1

• Allelic Composition: Slc38a4^em#Smtb/Slc38a4^em#Smtb
• Genetic Background: C57BL/6NSlc-Slc38a4^em#Ogu

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality ( J:280426 )

• typically 1-2 days after birth

embryo

abnormal trophoblast giant cell proliferation ( J:280426 )

• poor proliferation of chorion-derived trophoblast cells

abnormal spongiotrophoblast layer morphology ( J:280426 )

• reduced after E16.5

decreased trophoblast glycogen cell number ( J:280426 )

• at E16.5

thin placenta labyrinth ( J:280426 )

• at E11.5

decreased placenta weight ( J:280426 )

• at E13.5

growth/size/body

decreased body weight ( J:280426 )

decreased fetal size ( J:280426 )

• at E16.5

homeostasis/metabolism

abnormal circulating amino acid level ( J:280426 )

• reduced circulating tryptophan levels

decreased circulating glutamine level ( J:280426 )

• at E19.5

decreased circulating histidine level ( J:280426 )

• at E19.5

decreased circulating isoleucine level ( J:280426 )

• at E19.5

decreased circulating lysine level ( J:280426 )

• at E19.5

cellular

abnormal trophoblast giant cell proliferation ( J:280426 )

• poor proliferation of chorion-derived trophoblast cells

Genotype
MGI:6403626

ht2

• Allelic Composition: Slc38a4^em#Smtb/Slc38a4⁺
• Genetic Background: C57BL/6NSlc-Slc38a4^em#Ogu

mortality/aging

postnatal lethality ( J:280426 )

• typically 1-2 days after birth when the allele is inherited paternally

• however, mice exhibit normal survival when the allele is inherited maternally

embryo

abnormal trophoblast giant cell proliferation ( J:280426 )

• poor proliferation of chorion-derived trophoblast cells when the allele is inherited paternally

abnormal spongiotrophoblast layer morphology ( J:280426 )

• reduced after E16.5 when the allele is inherited paternally

decreased trophoblast glycogen cell number ( J:280426 )

• at E16.5 when the allele is inherited paternally

thin placenta labyrinth ( J:280426 )

• at E11.5 when the allele is inherited paternally

decreased placenta weight ( J:280426 )

• at E13.5 when the allele is inherited paternally

• however, mice exhibit normal placental weight when the allele is inherited maternally

growth/size/body

decreased body weight ( J:280426 )

• when the allele is inherited paternally

• however, mice exhibit normal body weight when the allele is inherited maternally

decreased fetal size ( J:280426 )

• at E16.5 when the allele is inherited paternally

homeostasis/metabolism

decreased circulating glutamine level ( J:280426 )

• at E19.5 when the allele is inherited paternally

decreased circulating glycine level ( J:280426 )

• at E19.5 when the allele is inherited paternally

decreased circulating histidine level ( J:280426 )

• at E19.5 when the allele is inherited paternally

decreased circulating isoleucine level ( J:280426 )

• at E19.5 when the allele is inherited paternally

decreased circulating serine level ( J:280426 )

• at E19.5 when the allele is inherited paternally

decreased circulating valine level ( J:280426 )

• at E19.5 when the allele is inherited paternally

cellular

abnormal trophoblast giant cell proliferation ( J:280426 )

• poor proliferation of chorion-derived trophoblast cells when the allele is inherited paternally