About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		1700028K03Rikem1Jzc
endonuclease-mediated mutation 1, Zi-Jiang Chen
MGI:6402900
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		1700028K03Rikem1Jzc/1700028K03Rikem1Jzc C57BL/6-1700028K03Rikem1Jzc MGI:6402902


Genotype
MGI:6402902
hm1
Allelic
Composition		 1700028K03Rikem1Jzc/1700028K03Rikem1Jzc
Genetic
Background		 C57BL/6-1700028K03Rikem1Jzc
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
1700028K03Rikem1Jzc mutation (0 available); any 1700028K03Rik mutation (17 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
decreased oocyte number ( J:285969 )
• almost not oocytes at P1however, normal oocytes are present at E17.5
absent oocytes ( J:285969 )
• at P6
azoospermia ( J:285969 )
• lack of post-meiotic cell types at P35
abnormal female meiosis I arrest ( J:285969 )
• very few normal pachytene-stage oocytes at E17.5 with severe desynapsis problems
arrest of male meiosis ( J:285969 )
• at the pachytene stage
small ovary ( J:285969 )
• underdeveloped; almost complete absence at 6 weeks of age

homeostasis/metabolism
abnormal double-strand DNA break repair ( J:285969 )
• in spermatocyte and oocytes with impaired crossover formation secondary to instable synapsis

endocrine/exocrine glands
small ovary ( J:285969 )
• underdeveloped; almost complete absence at 6 weeks of age

cellular
decreased oocyte number ( J:285969 )
• almost not oocytes at P1however, normal oocytes are present at E17.5
absent oocytes ( J:285969 )
• at P6
azoospermia ( J:285969 )
• lack of post-meiotic cell types at P35
abnormal female meiosis I arrest ( J:285969 )
• very few normal pachytene-stage oocytes at E17.5 with severe desynapsis problems
arrest of male meiosis ( J:285969 )
• at the pachytene stage
abnormal double-strand DNA break repair ( J:285969 )
• in spermatocyte and oocytes with impaired crossover formation secondary to instable synapsis




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory