All Phenotypes Rnu11<tm1.1Rank> MGI Mouse

nervous system

• significantly reduced number of RGCs in pallium of E13 and E14 embryos

• normal number of RGCs in pallium of E12 embryos

abnormal pallium development ( J:266583 )

• significantly thinner than wildtype in E14 embryos

• normal thickness in E13 embryos

absent hippocampus ( J:266583 )

• significantly reduced number of proliferating NPCs in pallium of E13 and E14 embryos

• significantly reduced number of intermediate progenitor cells (IPCs) in pallium of E13 and E14 embryos

• significantly reduced number of RGCs in pallium of E13 and E14 embryos

• normal number of proliferating NPCs in pallium of E12 embryos

• normal number of IPCs in pallium of E12 embryos

• normal number of RGCs in pallium of E12 embryos

decreased neuron number ( J:266583 )

• significantly reduced number of neurons in pallium of E14 embryos

• normal number of neurons in pallium of E12 and E13 embryos

cellular

increased cell death ( J:266583 )

• in pallium of E12-14 embryos

• significantly reduced number of RGCs in pallium of E13 and E14 embryos

• normal number of RGCs in pallium of E12 embryos

growth/size/body

microcephaly ( J:266583 )

• owing to decrease in number of neuronal progenitor cells

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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