Phenotypes associated with this allele

• Allele Symbol: Iqsec2^em1Alev
• Allele Name: endonuclease-mediated mutation 1, Andrew P Levy
• Allele ID: MGI:6393275
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Iqsec2^em1Alev/Iqsec2^em1Alev	C57BL/6J-Iqsec2^em1Alev	MGI:6393300

Genotype
MGI:6393300

hm1

• Allelic Composition: Iqsec2^em1Alev/Iqsec2^em1Alev
• Genetic Background: C57BL/6J-Iqsec2^em1Alev

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:280198 )

N • normal time spent in center compared to periphery in open filed test

N • normal behavior in rotarod test

N • normal preference for interaction with social stimulus over novel object in three-chamber social arena test

impaired spatial learning ( J:280198 )

♀ • increased latency to find hidden platform on 1st and 4th day of training in Morris water maze test

♀ • reduced time spent in target quadrant in Morris water maze test

abnormal response to novelty ( J:280198 )

• trend towards less time spent with social stimulus than wildtype in three-chamber social arena test

abnormal response to social novelty ( J:280198 )

• normal preference for interaction with novel mouse over familiar mouse

• significantly more time spent with novel mouse than wildtype

increased locomotor activity ( J:280198 )

• increased locomotor activity (total distance travelled) and speed in open field test

nervous system

abnormal CNS synaptic transmission ( J:280198 )

• significantly lower fEPSP slope/fiber volley in the dendritic region of hippocampal CA1 pyramidal neurons