All Phenotypes Dhx15<tm1c(EUCOMM)Wtsi> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Dhx15^{tm1c(EUCOMM)Wtsi}
targeted mutation 1c, Wellcome Trust Sanger Institute
MGI:6393262

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Dhx15^{tm1c(EUCOMM)Wtsi}/Dhx15^{tm1c(EUCOMM)Wtsi} Cd19^tm1(cre)Cgn/Cd19⁺	involves: 129P2/OlaHsd * C3H * C57BL/6N	MGI:6393270
cn2	Dhx15^{tm1c(EUCOMM)Wtsi}/Dhx15^{tm1c(EUCOMM)Wtsi} Tg(Cd4-cre)1Cwi/0	involves: C3H * C57BL/6N * DBA/2	MGI:6393268

Allelic Composition	Dhx15^{tm1c(EUCOMM)Wtsi}/Dhx15^{tm1c(EUCOMM)Wtsi} Cd19^tm1(cre)Cgn/Cd19⁺
Genetic Background	involves: 129P2/OlaHsd * C3H * C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19^tm1(cre)Cgn mutation (11 available); any Cd19 mutation (56 available)
Dhx15^{tm1c(EUCOMM)Wtsi} mutation (0 available); any Dhx15 mutation (38 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased B cell proliferation ( J:284624 )

• in a competitive fitness assay upon activation

abnormal B cell differentiation ( J:284624 )

decreased B cell number ( J:284624 )

• 4-fold reduction, not restricted to a particular B cell subtype

• 4-fold reduction of CD3+ splenic B cells

decreased pre-B cell number ( J:284624 )

• in the bone marrow

decreased spleen weight ( J:284624 )

spleen hypoplasia ( J:284624 )

cellular

decreased B cell proliferation ( J:284624 )

• in a competitive fitness assay upon activation

hematopoietic system

decreased B cell proliferation ( J:284624 )

• in a competitive fitness assay upon activation

abnormal B cell differentiation ( J:284624 )

decreased B cell number ( J:284624 )

• 4-fold reduction, not restricted to a particular B cell subtype

• 4-fold reduction of CD3+ splenic B cells

decreased pre-B cell number ( J:284624 )

• in the bone marrow

decreased spleen weight ( J:284624 )

spleen hypoplasia ( J:284624 )

Allelic Composition	Dhx15^{tm1c(EUCOMM)Wtsi}/Dhx15^{tm1c(EUCOMM)Wtsi} Tg(Cd4-cre)1Cwi/0
Genetic Background	involves: C3H * C57BL/6N * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dhx15^{tm1c(EUCOMM)Wtsi} mutation (0 available); any Dhx15 mutation (38 available)
Tg(Cd4-cre)1Cwi mutation (10 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

decreased CD4-positive, alpha-beta T cell number ( J:284624 )

decreased CD8-positive, alpha-beta T cell number ( J:284624 )

immune system

decreased CD4-positive, alpha-beta T cell number ( J:284624 )

decreased CD8-positive, alpha-beta T cell number ( J:284624 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 05/07/2024 MGI 6.23