All Phenotypes Gpr63<em2Rstot> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Gpr63^em2Rstot
endonuclease-mediated mutation 2, Rolf W Stottmann
MGI:6391253

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Gpr63^em2Rstot/Gpr63^em2Rstot Ttc21b^aln/Ttc21b^aln	involves: A/J * C57BL/6 * FVB	MGI:6392828
cx2	Gpr63^em1Rstot/Gpr63^em2Rstot Ttc21b^aln/Ttc21b^aln	involves: A/J * C57BL/6 * FVB	MGI:6392831

Allelic Composition	Gpr63^em2Rstot/Gpr63^em2Rstot Ttc21b^aln/Ttc21b^aln
Genetic Background	involves: A/J * C57BL/6 * FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gpr63^em2Rstot mutation (0 available); any Gpr63 mutation (27 available)
Ttc21b^aln mutation (0 available); any Ttc21b mutation (52 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

spina bifida cystica ( J:282171 )

• in 5 of 9 E10.5-14.5 embryos

spina bifida occulta ( J:282171 )

limbs/digits/tail

polydactyly ( J:282171 )

• in 1 of 9 E10.5-14.5 embryos and in 2 surviving (of 8) E17.5-18.5 embryos

mortality/aging

lethality throughout fetal growth and development, incomplete penetrance ( J:282171 )

• in 6 of 8 E17.5-18.5 embryos

nervous system

spina bifida cystica ( J:282171 )

• in 5 of 9 E10.5-14.5 embryos

spina bifida occulta ( J:282171 )

exencephaly ( J:282171 )

• in 2 surviving (of 8) E17.5-18.5 embryos and 8 of 9 E10.5-14.5 embryos

skeleton

spina bifida occulta ( J:282171 )

growth/size/body

spina bifida cystica ( J:282171 )

• in 5 of 9 E10.5-14.5 embryos

Allelic Composition	Gpr63^em1Rstot/Gpr63^em2Rstot Ttc21b^aln/Ttc21b^aln
Genetic Background	involves: A/J * C57BL/6 * FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gpr63^em1Rstot mutation (0 available); any Gpr63 mutation (27 available)
Gpr63^em2Rstot mutation (0 available); any Gpr63 mutation (27 available)
Ttc21b^aln mutation (0 available); any Ttc21b mutation (52 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

microcephaly ( J:282171 )

• 25% reduction in forebrain area compared to Ttc21b^aln/ Ttc21b^aln;Gpr63^em1Rstot/Gpr63^rs13477613-T mice

nervous system

forebrain hypoplasia ( J:282171 )

• 25% reduction in forebrain area compared to Ttc21b^aln/ Ttc21b^aln;Gpr63^em1Rstot/Gpr63^rs13477613-T mice

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