Analysis Tools|
Allele Symbol Allele Name Allele ID |
Traf7em1(IMPC)Tcp endonuclease-mediated mutation 1, The Centre for Phenogenomics MGI:6388361 |
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| Summary |
3 genotypes
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Data Sources
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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IMPC - TCP
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IMPC - TCP
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IMPC - TCP
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• at E10.5, most homozygous embryos exhibit abnormal cardia tissue, some with enlarged hearts and some with pericardial edema
• however, heart development is normal at E9.5
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• at E10.5, some homozygous embryos exhibit enlarged hearts
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• at E10.5, some homozygous embryos exhibit pericardial edema
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• at E9.5, some homozygous embryos exhibit abnormal blood deposition in the embryo or in the yolk sac
• abnormal blood deposition is often detected at E10.5
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• at E10.5, some homozygous embryos exhibit abnormal blood deposition in the pericardial sac
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• at E10.5, some homozygous embryos exhibit abnormal blood deposition in the midbrain
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• at E10.5, nearly all homozygous embryos exhibit an abnormal head shape
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• at E10.5, section analysis shows a reduction in cellular density in delayed homozygous embryos
• however, germ layer patterning is normal at E9.5-E10.5 and both heart and liver development are normal at E9.5
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• at E9.5, some homozygous embryos exhibit incomplete turning
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• at E10.5, most homozygous embryos exhibit abnormal branchial arch development
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• a fraction of homozygous embryos are developmentally delayed at E9.5; nearly all are delayed at E10.5
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• at E10.5, placentas exhibit multiple labyrinth zone defects
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• at E10.5, the Tfeb+ labyrinth trophoblast layer is reduced in thickness but shows increased Tfeb signal intensity, suggesting an increased density of Tfeb+ cells
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• at E10.5, yolk sacs dissected intact are vascularized but appear paler than in control littermates
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• at E10.5, chorioallantoic branching is nearly absent, as Gcm1 expression is sparse and remains at the chorioallantoic interface
• however, placentas appear properly developed at E9.5
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• at E10.5, some homozygous embryos exhibit enlarged hearts
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• at E10.5, nearly all homozygous embryos exhibit an abnormal head shape
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• a fraction of homozygous embryos are developmentally delayed at E9.5; nearly all are delayed at E10.5
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• at E10.5, heads sections are less cellularly dense relative to those in control littermates
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• at E10.5, some homozygous embryos exhibit abnormal blood deposition in the pericardial sac
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• at E10.5, some homozygous embryos exhibit pericardial edema
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• homozygous embryos are present in Mendelian ratios at E8.5-E10.5; all homozygous embryos dissected at E11.5 are resorbing
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• at E10.5, some homozygous embryos exhibit abnormal blood deposition in the midbrain
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Data Sources
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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IMPC - TCP
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IMPC - TCP
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IMPC - TCP
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/30/2025 MGI 6.24 |
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