Phenotypes associated with this allele

• Allele Symbol: Ddx46^em1(IMPC)Tcp
• Allele Name: endonuclease-mediated mutation 1, The Centre for Phenogenomics
• Allele ID: MGI:6388358
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ddx46^em1(IMPC)Tcp/Ddx46^em1(IMPC)Tcp	C57BL/6N-Ddx46^em1(IMPC)Tcp/Cmmr	MGI:6492795
ht2	Ddx46^em1(IMPC)Tcp/Ddx46^+	C57BL/6N-Ddx46^em1(IMPC)Tcp/Cmmr	MGI:6696712

Genotype
MGI:6492795

hm1

• Allelic Composition: Ddx46^em1(IMPC)Tcp/Ddx46^em1(IMPC)Tcp
• Genetic Background: C57BL/6N-Ddx46^em1(IMPC)Tcp/Cmmr

Data Sources

IMPC Data for Ddx46

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Ddx46^em1(IMPC)Tcp/Ddx46^em1(IMPC)Tcp mice exhibit embryonic lethality, with embryos recovered at E3.5 as blastocysts but not at E7.5. Blastocysts hatch from the zona pellucida but form irregular outgrowths.

mortality/aging

embryonic lethality prior to organogenesis ( J:211773 )

IMPC - TCP

preweaning lethality, complete penetrance ( J:211773 )

IMPC - TCP

embryonic lethality between implantation and somite formation, complete penetrance ( J:279207 )

• blastocysts are present at E3.5 (14% versus expected 25%, n=29); no homozygous embryos are recovered at E7.5

• however, excess resorption sites suggest that embryos elicit a decidual response in vivo

reproductive system

abnormal embryo implantation ( J:279207 )

• in vitro, blastocysts hatch from the zona pellucida but form irregular outgrowths after 3 days in culture

Genotype
MGI:6696712

ht2

• Allelic Composition: Ddx46^em1(IMPC)Tcp/Ddx46⁺
• Genetic Background: C57BL/6N-Ddx46^em1(IMPC)Tcp/Cmmr

Data Sources

IMPC Data for Ddx46

hematopoietic system

decreased mean corpuscular hemoglobin ( J:211773 )

IMPC - TCP

immune system

enlarged lymph nodes ( J:211773 )

♂

IMPC - TCP